Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 105670..106397 | Replicon | plasmid pKqs_SB610_4 |
| Accession | NZ_CP084774 | ||
| Organism | Klebsiella quasipneumoniae subsp. similipneumoniae strain SB610 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A663AUB1 |
| Locus tag | LGM29_RS28650 | Protein ID | WP_000558568.1 |
| Coordinates | 105670..105981 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | V0AHC4 |
| Locus tag | LGM29_RS28655 | Protein ID | WP_000990392.1 |
| Coordinates | 105978..106397 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM29_RS28625 (LGM29_28625) | 101634..101798 | - | 165 | Protein_104 | N-acetyltransferase | - |
| LGM29_RS28630 (LGM29_28630) | 101869..102849 | + | 981 | WP_000019450.1 | IS5-like element ISKpn26 family transposase | - |
| LGM29_RS28635 (LGM29_28635) | 102962..104341 | + | 1380 | WP_226550183.1 | LutB/LldF family L-lactate oxidation iron-sulfur protein | - |
| LGM29_RS28640 (LGM29_28640) | 104334..105029 | + | 696 | WP_000370412.1 | lactate utilization protein C | - |
| LGM29_RS28645 (LGM29_28645) | 105079..105459 | - | 381 | Protein_108 | gluconate permease | - |
| LGM29_RS28650 (LGM29_28650) | 105670..105981 | + | 312 | WP_000558568.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LGM29_RS28655 (LGM29_28655) | 105978..106397 | + | 420 | WP_000990392.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LGM29_RS28660 (LGM29_28660) | 106434..107636 | - | 1203 | WP_003031541.1 | hypothetical protein | - |
| LGM29_RS28665 (LGM29_28665) | 107629..107958 | - | 330 | WP_000121260.1 | hypothetical protein | - |
| LGM29_RS28670 (LGM29_28670) | 107955..108614 | - | 660 | WP_176759338.1 | maturation control protein | - |
| LGM29_RS28675 (LGM29_28675) | 109017..109130 | - | 114 | Protein_114 | IS1 family transposase | - |
| LGM29_RS28680 (LGM29_28680) | 109267..109590 | + | 324 | WP_157843664.1 | Tn7-like element transposition protein TnsE | - |
| LGM29_RS28685 (LGM29_28685) | 109754..110662 | + | 909 | WP_117250874.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mcr-10 | - | 1..124980 | 124980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12372.11 Da Isoelectric Point: 10.0935
>T219358 WP_000558568.1 NZ_CP084774:105670-105981 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MHVVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE
MHVVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE
Download Length: 312 bp
>T219358 NZ_CP116347:c4174700-4174290 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15534.71 Da Isoelectric Point: 4.4702
>AT219358 WP_000990392.1 NZ_CP084774:105978-106397 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA
Download Length: 420 bp
>AT219358 NZ_CP116347:c4174947-4174681 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AUB1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0AHC4 |