Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4014870..4015530 Replicon chromosome
Accession NZ_CP084767
Organism Klebsiella variicola subsp. tropica strain CDC4241-71

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGN97_RS19360 Protein ID WP_136086126.1
Coordinates 4014870..4015223 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGN97_RS19365 Protein ID WP_136086127.1
Coordinates 4015228..4015530 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN97_RS19340 (LGN97_19340) 4010295..4011917 - 1623 WP_100730325.1 alpha/beta hydrolase -
LGN97_RS19345 (LGN97_19345) 4012188..4012433 + 246 WP_100675364.1 signal transduction protein PmrD -
LGN97_RS19350 (LGN97_19350) 4012563..4014017 + 1455 WP_226682157.1 AMP nucleosidase -
LGN97_RS19355 (LGN97_19355) 4014106..4014264 - 159 WP_165784169.1 hypothetical protein -
LGN97_RS19360 (LGN97_19360) 4014870..4015223 + 354 WP_136086126.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGN97_RS19365 (LGN97_19365) 4015228..4015530 + 303 WP_136086127.1 XRE family transcriptional regulator Antitoxin
LGN97_RS19375 (LGN97_19375) 4016036..4017472 - 1437 WP_165784170.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
LGN97_RS19390 (LGN97_19390) 4017795..4018127 - 333 WP_074385360.1 type II toxin-antitoxin system PemK/MazF family toxin -
LGN97_RS19395 (LGN97_19395) 4018128..4018385 - 258 WP_136086128.1 antitoxin -
LGN97_RS19400 (LGN97_19400) 4018913..4020013 + 1101 WP_100675340.1 AarF/UbiB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13536.61 Da        Isoelectric Point: 10.3841

>T219341 WP_136086126.1 NZ_CP084767:4014870-4015223 [Klebsiella variicola subsp. tropica]
VWTIKTTDMFDRWFTSLNDIDRASVLAALLVLREKGPGLSRPYADTIRGPRYSNMKELRVQSRGIPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYHEMLAVADREFTNWLNRLKEKE

Download         Length: 354 bp

>T219341 NZ_CP116305:c4560486-4560334 [Xanthomonas perforans]
ATGAAGCGACTGCTGACACTGATGGTGCTGGCCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCGACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11165.96 Da        Isoelectric Point: 5.1976

>AT219341 WP_136086127.1 NZ_CP084767:4015228-4015530 [Klebsiella variicola subsp. tropica]
MGRTLEQLLIDEKPDVVAEAQAITKDILLNIHLAELREKVQKTQVEMAQDLGIKQPTVAGMEKPGRDLKLSTLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT219341 NZ_CP116305:c4560259-4560125 [Xanthomonas perforans]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGCGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References