Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 362445..363091 Replicon chromosome
Accession NZ_CP084767
Organism Klebsiella variicola subsp. tropica strain CDC4241-71

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGN97_RS01645 Protein ID WP_100729733.1
Coordinates 362445..362792 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGN97_RS01650 Protein ID WP_074387048.1
Coordinates 362792..363091 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN97_RS01635 (LGN97_01635) 358332..359765 + 1434 WP_061153091.1 glycogen synthase GlgA -
LGN97_RS01640 (LGN97_01640) 359783..362230 + 2448 WP_061153092.1 glycogen phosphorylase -
LGN97_RS01645 (LGN97_01645) 362445..362792 + 348 WP_100729733.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGN97_RS01650 (LGN97_01650) 362792..363091 + 300 WP_074387048.1 XRE family transcriptional regulator Antitoxin
LGN97_RS01655 (LGN97_01655) 363154..364662 - 1509 WP_074387049.1 glycerol-3-phosphate dehydrogenase -
LGN97_RS01660 (LGN97_01660) 364866..365195 + 330 WP_032733885.1 thiosulfate sulfurtransferase GlpE -
LGN97_RS01665 (LGN97_01665) 365246..366076 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
LGN97_RS01670 (LGN97_01670) 366126..366884 + 759 WP_136086069.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13465.54 Da        Isoelectric Point: 6.2300

>T219328 WP_100729733.1 NZ_CP084767:362445-362792 [Klebsiella variicola subsp. tropica]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGCPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
ILCAGNKDGMNEKRFYKEMITLADREFSKHLTKER

Download         Length: 348 bp

>T219328 NZ_CP116303:1695220-1695477 [Tenacibaculum finnmarkense]
ATGAAGTATACATTCGTTGACGAGTCTTGGGAAGATTATTTGTATTGGCAAAAAACAGACAAAAAAAAGTTAAAAAAAAT
AAATGAACTTCTAAAAGACATTGCTCGAAATCCTTTTGATGGGATTGGAAAACCAGAAGCACTAAAACATAAATACGCAG
GATTTTGGTCAAGACGAATTGATAGTGAGCATAGATTGATTTACCAATATCGAGAAGGAGAAATCTTAATTGCCAAATGT
AGATTCCATTATAACTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10853.63 Da        Isoelectric Point: 10.1464

>AT219328 WP_074387048.1 NZ_CP084767:362792-363091 [Klebsiella variicola subsp. tropica]
MATLKELMAKQNPESQQRIAAKAAEIRQSVALNLLREELQISQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT219328 NZ_CP116303:1694964-1695218 [Tenacibaculum finnmarkense]
ATGCAAATAACAACTGTTTCTGACTTCAGAAAAGATATTAAAAGTTACTTAGACAGAGTTATCAAAGACTTTGAAACATT
AATAATAAATCGCGGAAAAGATTCTGGAATTGTAGTTATGTCATTGCAGGAATACAATTCTTTAATGGCTACAAATCATG
AATTATCTTCACGAAAAAATGAATTAAGATTAGACTCTGCAATTGACAAACTAAAAAACGGAATGACCTTAAACAAAGAC
CTAATCGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References