Detailed information of TA system TA021929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 382982..383484
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: YE_RS01690
• Protein ID: WP_042661583.1
• Coordinates: 383230..383484 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A1JIL4
• Locus tag: YE_RS01685
• Protein ID: WP_011815401.1
• Coordinates: 382982..383233 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS01675 (YE0319)	378334..380079	+	1746	WP_162484200.1	ABC transporter ATP-binding protein/permease	-
YE_RS01680 (YE0320)	380064..382850	+	2787	WP_011815400.1	insulinase family protein	-
YE_RS01685 (YE0321)	382982..383233	+	252	WP_011815401.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
YE_RS01690	383230..383484	+	255	WP_042661583.1	Txe/YoeB family addiction module toxin	Toxin
YE_RS01695 (YE0322)	383508..385844	-	2337	WP_042661692.1	mechanosensitive ion channel family protein	-
YE_RS01700 (YE0323)	386263..388395	+	2133	WP_011815403.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10143.71 Da
• Isoelectric Point: 9.7957

>T21929 WP_042661583.1 NC_008800:383230-383484 [Yersinia enterocolitica subsp. enterocolitica 8081]
VKIIFSSCSWEDYLYWQQTDKKILKRINGLVKNIQRTPFEVKGKPEPLKHNLAGFWSRRMTEEHRLVYEVSGDNLLIAAY
RYYY

Nucleotide

• Length: 255 bp

>T21929 NC_008800:383230-383484 [Yersinia enterocolitica subsp. enterocolitica 8081]
GTGAAAATTATATTTTCCAGTTGTTCTTGGGAGGATTATCTTTATTGGCAACAAACGGATAAGAAAATCCTCAAACGCAT
TAATGGGTTAGTAAAAAATATTCAAAGAACGCCATTTGAGGTAAAGGGCAAACCAGAACCCCTTAAACATAATCTGGCAG
GGTTCTGGTCACGGAGGATGACAGAAGAGCACAGACTTGTTTATGAGGTTTCCGGTGATAATTTATTAATTGCTGCTTAT
CGTTACTATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9389.63 Da
• Isoelectric Point: 4.6096

>AT21929 WP_011815401.1 NC_008800:382982-383233 [Yersinia enterocolitica subsp. enterocolitica 8081]
MRTISYSEARQNLSTTMVQTVEDRAPILITRQNGTSCVLMSLEEYESLEETAYLLRSPANAKHLMDSIEELRAGKGIQRE
LEA

Nucleotide

• Length: 252 bp

>AT21929 NC_008800:382982-383233 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGAGAACAATTAGTTATAGTGAAGCGCGCCAGAATTTGTCGACAACGATGGTGCAAACGGTTGAGGATCGAGCCCCCAT
CCTCATCACCCGTCAAAATGGGACTTCTTGTGTTCTTATGTCACTTGAAGAATATGAATCATTGGAAGAAACTGCTTATT
TATTGCGTTCACCAGCAAACGCGAAGCACTTGATGGACTCAATTGAAGAGTTGAGAGCAGGAAAAGGAATTCAAAGGGAA
CTTGAAGCGTGA

Structures

Antitoxin

• AlphaFold DB: A1JIL4