Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 210894..211515 Replicon chromosome
Accession NZ_CP084752
Organism UNVERIFIED_ORG: Kinneretia sp. XES5

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LHK14_RS01210 Protein ID WP_226919561.1
Coordinates 210894..211175 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LHK14_RS01215 Protein ID WP_226919562.1
Coordinates 211204..211515 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK14_RS01155 (LHK14_01155) 206561..206824 + 264 WP_226919550.1 hypothetical protein -
LHK14_RS01160 (LHK14_01160) 206856..207173 + 318 WP_226919551.1 hypothetical protein -
LHK14_RS01165 (LHK14_01165) 207258..207503 - 246 WP_226919552.1 hypothetical protein -
LHK14_RS01170 (LHK14_01170) 207500..207700 - 201 WP_226919553.1 hypothetical protein -
LHK14_RS01175 (LHK14_01175) 207936..208238 + 303 WP_226919554.1 hypothetical protein -
LHK14_RS01180 (LHK14_01180) 208260..208493 + 234 WP_226919555.1 hypothetical protein -
LHK14_RS01185 (LHK14_01185) 208483..208812 + 330 WP_226919556.1 hypothetical protein -
LHK14_RS01190 (LHK14_01190) 208822..209022 + 201 WP_226919557.1 hypothetical protein -
LHK14_RS01195 (LHK14_01195) 209158..209385 + 228 WP_226919558.1 hypothetical protein -
LHK14_RS01200 (LHK14_01200) 209375..209704 - 330 WP_226919559.1 hypothetical protein -
LHK14_RS01205 (LHK14_01205) 210096..210338 - 243 WP_226919560.1 hypothetical protein -
LHK14_RS01210 (LHK14_01210) 210894..211175 + 282 WP_226919561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LHK14_RS01215 (LHK14_01215) 211204..211515 + 312 WP_226919562.1 HigA family addiction module antitoxin Antitoxin
LHK14_RS01220 (LHK14_01220) 211880..212194 + 315 WP_226919563.1 EthD family reductase -
LHK14_RS01225 (LHK14_01225) 212279..212542 - 264 WP_226919564.1 hypothetical protein -
LHK14_RS01230 (LHK14_01230) 212768..213589 - 822 WP_226919565.1 histidine utilization repressor -
LHK14_RS01235 (LHK14_01235) 213610..214956 - 1347 WP_249228402.1 formimidoylglutamate deiminase -
LHK14_RS01240 (LHK14_01240) 215079..216302 + 1224 WP_226919567.1 imidazolonepropionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-99)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10403.83 Da        Isoelectric Point: 8.0358

>T219281 WP_226919561.1 NZ_CP084752:210894-211175 [Kinneretia sp. XES5]
VIRSYKDAKTETLASGKAPKGFPADIVRATIRKLTMIANAVVLDDLRSPPGNRLEALKGDREGQHSIRINDQWRICFVWN
EGGAENVEIVDYH

Download         Length: 282 bp

>T219281 NZ_CP116241:c3429241-3429134 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11434.16 Da        Isoelectric Point: 4.4290

>AT219281 WP_226919562.1 NZ_CP084752:211204-211515 [Kinneretia sp. XES5]
MASILPPIHPGEILREEYLVPLDMSAGALAKKLGVPRTRIERLATEQSAVTTDTALRLAKFFKTTPEFWMNMQASYDIKI
AFAELEDELASIPEIENDDAKAA

Download         Length: 312 bp

>AT219281 NZ_CP116241:3429289-3429355 [Escherichia coli]
GGTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References