Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 4754315..4755666 | Replicon | chromosome |
| Accession | NZ_CP084741 | ||
| Organism | Pectobacterium carotovorum strain A077-S18-O15 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | - |
| Locus tag | LHL03_RS21215 | Protein ID | WP_040035580.1 |
| Coordinates | 4754626..4755666 (+) | Length | 347 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | A0A837DJW1 |
| Locus tag | LHL03_RS21210 | Protein ID | WP_039508346.1 |
| Coordinates | 4754315..4754629 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LHL03_RS21190 (LHL03_21190) | 4749947..4751650 | + | 1704 | WP_039508349.1 | ABC transporter ATP-binding protein | - |
| LHL03_RS21195 (LHL03_21195) | 4751652..4752686 | + | 1035 | WP_226509684.1 | putative FMN-dependent luciferase-like monooxygenase | - |
| LHL03_RS21200 (LHL03_21200) | 4752683..4753816 | + | 1134 | WP_226509685.1 | alkylhydroperoxidase domain protein | - |
| LHL03_RS21205 (LHL03_21205) | 4754004..4754330 | + | 327 | WP_226509686.1 | helix-turn-helix domain-containing protein | - |
| LHL03_RS21210 (LHL03_21210) | 4754315..4754629 | + | 315 | WP_039508346.1 | HipA N-terminal domain-containing protein | Antitoxin |
| LHL03_RS21215 (LHL03_21215) | 4754626..4755666 | + | 1041 | WP_040035580.1 | HipA domain-containing protein | Toxin |
| LHL03_RS21220 (LHL03_21220) | 4755727..4756350 | - | 624 | WP_039474438.1 | LysE family translocator | - |
| LHL03_RS21225 (LHL03_21225) | 4756629..4757384 | + | 756 | WP_226509687.1 | thiol:disulfide interchange protein DsbG | - |
| LHL03_RS21230 (LHL03_21230) | 4757418..4758323 | - | 906 | WP_226509688.1 | siderophore-interacting protein | - |
| LHL03_RS21235 (LHL03_21235) | 4758580..4758831 | + | 252 | WP_226509689.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LHL03_RS21240 (LHL03_21240) | 4758828..4759115 | + | 288 | WP_226509690.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LHL03_RS21245 (LHL03_21245) | 4759211..4760563 | - | 1353 | WP_137741166.1 | glutathione-disulfide reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 347 a.a. Molecular weight: 39523.45 Da Isoelectric Point: 6.6174
>T219274 WP_040035580.1 NZ_CP084741:4754626-4755666 [Pectobacterium carotovorum]
MTRCRILLTPLTHEEESATGYSRKGLKHLTGSMHASPALRFTRQQFMHDLPQAQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
AGEKFGKIRTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADFLKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI
MTRCRILLTPLTHEEESATGYSRKGLKHLTGSMHASPALRFTRQQFMHDLPQAQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
AGEKFGKIRTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADFLKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI
Download Length: 1041 bp
>T219274 NZ_CP116241:1838417-1838635 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11886.68 Da Isoelectric Point: 9.5753
>AT219274 WP_039508346.1 NZ_CP084741:4754315-4754629 [Pectobacterium carotovorum]
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSQTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSQTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS
Download Length: 315 bp
>AT219274 NZ_CP116241:1838017-1838391 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|