Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 511608..512110 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7W2E5L4
Locus tag LHL03_RS02350 Protein ID WP_039282578.1
Coordinates 511608..511862 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag LHL03_RS02355 Protein ID WP_039324900.1
Coordinates 511859..512110 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS02330 (LHL03_02330) 506761..508023 - 1263 WP_010296200.1 L-rhamnose isomerase -
LHL03_RS02335 (LHL03_02335) 508020..509510 - 1491 WP_138255873.1 rhamnulokinase -
LHL03_RS02340 (LHL03_02340) 509847..510686 + 840 WP_014913998.1 HTH-type transcriptional activator RhaS -
LHL03_RS02345 (LHL03_02345) 510711..511565 + 855 WP_040031929.1 helix-turn-helix domain-containing protein -
LHL03_RS02350 (LHL03_02350) 511608..511862 - 255 WP_039282578.1 Txe/YoeB family addiction module toxin Toxin
LHL03_RS02355 (LHL03_02355) 511859..512110 - 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LHL03_RS02360 (LHL03_02360) 512186..513892 - 1707 WP_138255872.1 ABC transporter ATP-binding protein -
LHL03_RS02365 (LHL03_02365) 513889..514755 - 867 WP_010285293.1 ABC transporter permease -
LHL03_RS02370 (LHL03_02370) 514748..515707 - 960 WP_029367586.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.79 Da        Isoelectric Point: 8.0353

>T219264 WP_039282578.1 NZ_CP084741:c511862-511608 [Pectobacterium carotovorum]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T219264 NZ_CP116239:c5296426-5295857 [Pseudomonas sp. TUM22785]
ATGTTCAATCCGCAACCGGTCATCCTGCAGCGTGGCGCCTTGCGCCTGGAACCGCTGACTGAGGCCGACATCACCGAGCT
CTCGGCCCTCGCTGAAGCCAACCGCGACGAACTGGTCTACATGAGCGGCCCGCTGCGCCCGGACTGGTACCGCCAGGGCC
TGGCCCAGCAGCGCGAAGGCCTGGCCGTGGTGTTCGCCATCCGCCTGGGCGACCGCCTGGTGGGCACCAGCCGTTTCGCG
GATTTCATGCCTGCCCTGCCGGCGGTGGAGATCGGCTGGACCTGGCTGGCCCGCAGCGAGCATGCCAGTGGCCTCAATGC
TTCGATCAAATACCTGATGCTGCGCCACGCCTTCGAGGAGTGGCAGGTGGTGCGTGTGCAACTGAAGACCGCGGGCAGCA
ACCTGCGCTCGCAGAAGGCCATCGAGAAGCTCGGTGCACAGCGCGAAGGGGTGCTGCGCAACAACCGCCGCCTGGCCGAT
GGGCGCCTCGACGACAGCGTGCTCTACAGCATCACCGACCGTGAATGGCCGGCGGTGAAGCAGGCCCTGGAAGCTTCCTT
CGGCAACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT219264 WP_039324900.1 NZ_CP084741:c512110-511859 [Pectobacterium carotovorum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT219264 NZ_CP116239:c5295854-5295009 [Pseudomonas sp. TUM22785]
ATGAGTGGCATCGGCGGCGAACAGACGCATTTCTGGCAGGCCAGCGAGCTCGGCGGTGTCGAGTTGCTGCATGCGCGCTA
CATCGAGCAGCGCTTCGCGCCCCATGTGCACGAGGGCTATGTCTTCACCGTGATCGAGTCCGGCGCCCAGCGTTTCCGCC
ACCGTGGCAGCGACCACCTGGCGGAGCAGGGCAGCATGGTGCTGATCAACCCCGACGAACTCCACACCGGCTCCAAGGCC
CACGACGAAGGCTGGCGCTATCGCGGTTTCTACCCCGATCTGCAGCGGGTGACCGAGGTGCTGGAGGAGCTGGATATCTC
CACGGGCGGCCTGCCCACCTTCGCTGACAGCGTGCTGCACGACCCCGAGGTGACCAATCGCTTCCTCGCCCTGCACCGTT
TGCTGGAGCAGGGCGCCACGGCGCTGGAGCAGCAGATGGCCTGGCGCGAAGCGGTACTGCTGCTGTTTCAACGCTATGCA
CGCATCGGCGCGCCCCGTGCCGCCGGGCATGAGCCCCAGGCGGTGACCCTTGCCCGCGAGCTGTTGGCTTCACGCCTGGC
CGAACCGCCATCCCTGGAGGAACTGGCCGCAGCGGTAGGGCTCTCGCCTTTCCACTTTGCCCGGGTGTTCCGCCGGGCCA
CCGGGTTACCGCCGCATTCCTGGCTCAAGCAGCGTCGCCTGGAGCAGGCGCGGGCATTGCTGCGCGAGGGCTGCGCGCCG
CTGTCGGTGGCCATGCAACTGGGCTTCGCCGACCAGAGCCATTTGAGCCGGCAGTTCAAGCAGACCTATGGTGTGGCGCC
GGGTGAATACCGCAGCGCCTGCGCAAGATCGTTCAAGACTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E5L4

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References