219241

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 24693..25351 Replicon plasmid pHKU3b
Accession NZ_CP084735
Organism Acinetobacter baumannii strain HKU3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LHJ62_RS19580 Protein ID WP_000312250.1
Coordinates 24992..25351 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LHJ62_RS19575 Protein ID WP_001096429.1
Coordinates 24693..24992 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHJ62_RS19540 (LHJ62_19540) 19858..20487 + 630 WP_000701002.1 hypothetical protein -
LHJ62_RS19545 (LHJ62_19545) 20527..21036 + 510 WP_001043200.1 hypothetical protein -
LHJ62_RS19550 (LHJ62_19550) 21118..21630 + 513 WP_000840065.1 hypothetical protein -
LHJ62_RS19555 (LHJ62_19555) 21686..22015 + 330 WP_000459117.1 hypothetical protein -
LHJ62_RS19560 (LHJ62_19560) 22052..22780 + 729 WP_001022819.1 hypothetical protein -
LHJ62_RS19565 (LHJ62_19565) 23016..23570 + 555 WP_000790082.1 hypothetical protein -
LHJ62_RS19570 (LHJ62_19570) 23620..24156 + 537 WP_226511746.1 hypothetical protein -
LHJ62_RS19575 (LHJ62_19575) 24693..24992 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
LHJ62_RS19580 (LHJ62_19580) 24992..25351 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LHJ62_RS19585 (LHJ62_19585) 25552..26118 + 567 WP_000710385.1 hypothetical protein -
LHJ62_RS19590 (LHJ62_19590) 26167..26349 + 183 WP_000373385.1 hypothetical protein -
LHJ62_RS19595 (LHJ62_19595) 26416..27114 + 699 WP_000873188.1 hypothetical protein -
LHJ62_RS19600 (LHJ62_19600) 27253..27636 + 384 WP_000654348.1 hypothetical protein -
LHJ62_RS19605 (LHJ62_19605) 27703..28461 + 759 WP_001053128.1 hypothetical protein -
LHJ62_RS19610 (LHJ62_19610) 28513..28848 + 336 WP_000653925.1 hypothetical protein -
LHJ62_RS19615 (LHJ62_19615) 29714..30028 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..69524 69524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T219241 WP_000312250.1 NZ_CP084735:c25351-24992 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T219241 NZ_CP116223:3114853-3115422 [Proteus mirabilis]
ATGACAAACTATACTGTTTTGCTTGATGCCTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTTGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGACAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAATACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGAATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCCCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT219241 WP_001096429.1 NZ_CP084735:c24992-24693 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT219241 NZ_CP116223:3114401-3114853 [Proteus mirabilis]
ATGAATACGATAAGTGAGAGACTTAGTACTGAAGATATTGCATTAGCAAAATTAAGTAGCCAAGAGCTATCCGCTGTTAT
GGATATTAATGGCAAAACGCAGAAGCTATCCATTATAGATAAGACGGGTAATAATCATATTGTACAAATACCAAATAGTG
CATTACGCCTAATGATTGAAATTCTTACTCAACTAGGGCAAGGGAATACTGTTAGTATCACACCAATCCATGCTGAGCTA
ACGACACAGGAAGCGGCTGATATACTCAATATGTCCCGTCCTACATTTGTAAAATTATTAGATACACGAGCGATACCCTA
CTCTAGAAAAGGAAATCGTAGGAAAGTTGCTTATGCTGATATTGTTGCTTATAAAAATGAATTGGAGCAAAAACGACTTG
ATGCCCTTGCTGAATTATCGCAATTAGATCAAGAAATGGATATGGGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References