Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 24692..25350 Replicon plasmid pHKU7b
Accession NZ_CP084723
Organism Acinetobacter baumannii strain HKU7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LHJ63_RS19590 Protein ID WP_000312250.1
Coordinates 24991..25350 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LHJ63_RS19585 Protein ID WP_001096429.1
Coordinates 24692..24991 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHJ63_RS19550 (LHJ63_19550) 19858..20487 + 630 WP_000701002.1 hypothetical protein -
LHJ63_RS19555 (LHJ63_19555) 20527..21036 + 510 WP_001043200.1 hypothetical protein -
LHJ63_RS19560 (LHJ63_19560) 21118..21630 + 513 WP_000840065.1 hypothetical protein -
LHJ63_RS19565 (LHJ63_19565) 21686..22015 + 330 WP_000459117.1 hypothetical protein -
LHJ63_RS19570 (LHJ63_19570) 22052..22780 + 729 WP_001022819.1 hypothetical protein -
LHJ63_RS19575 (LHJ63_19575) 23016..23570 + 555 WP_000790082.1 hypothetical protein -
LHJ63_RS19580 (LHJ63_19580) 23620..24156 + 537 WP_226511746.1 hypothetical protein -
LHJ63_RS19585 (LHJ63_19585) 24692..24991 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
LHJ63_RS19590 (LHJ63_19590) 24991..25350 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LHJ63_RS19595 (LHJ63_19595) 25551..26117 + 567 WP_000710385.1 hypothetical protein -
LHJ63_RS19600 (LHJ63_19600) 26166..26348 + 183 WP_000373385.1 hypothetical protein -
LHJ63_RS19605 (LHJ63_19605) 26415..27113 + 699 WP_000873188.1 hypothetical protein -
LHJ63_RS19610 (LHJ63_19610) 27252..27635 + 384 WP_000654348.1 hypothetical protein -
LHJ63_RS19615 (LHJ63_19615) 27702..28460 + 759 WP_001053128.1 hypothetical protein -
LHJ63_RS19620 (LHJ63_19620) 28512..28847 + 336 WP_000653925.1 hypothetical protein -
LHJ63_RS19625 (LHJ63_19625) 29714..30028 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..69524 69524


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T219229 WP_000312250.1 NZ_CP084723:c25350-24991 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T219229 NZ_CP116216:c55340-54858 [Klebsiella michiganensis]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT219229 WP_001096429.1 NZ_CP084723:c24991-24692 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT219229 NZ_CP116216:c55594-55328 [Klebsiella michiganensis]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References