Detailed information of TA system TA219206

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 79973..80242
• Replicon: plasmid p2
• Accession: NZ_CP084707
• Organism: Klebsiella pneumoniae strain KP1064WHY

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: K8U55_RS28950
• Protein ID: WP_001372321.1
• Coordinates: 80117..80242 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	79973..80038 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8U55_RS28920	75683..76210	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
K8U55_RS28925	76268..76501	+	234	WP_000006003.1	DUF905 family protein	-
K8U55_RS28930	76562..78585	+	2024	Protein_111	ParB/RepB/Spo0J family partition protein	-
K8U55_RS28935	78654..79088	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
K8U55_RS28940	79085..79804	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	79816..80040	+	225	NuclAT_0	-	-
-	79816..80040	+	225	NuclAT_0	-	-
-	79816..80040	+	225	NuclAT_0	-	-
-	79816..80040	+	225	NuclAT_0	-	-
-	79973..80038	-	66	-	-	Antitoxin
K8U55_RS28945	80026..80175	+	150	Protein_114	plasmid maintenance protein Mok	-
K8U55_RS28950	80117..80242	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
K8U55_RS28955	80561..80857	-	297	Protein_116	hypothetical protein	-
K8U55_RS28960	81159..81455	+	297	WP_001272251.1	hypothetical protein	-
K8U55_RS28965	81566..82387	+	822	WP_001234445.1	DUF932 domain-containing protein	-
K8U55_RS28970	82684..83331	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
K8U55_RS28975	83608..83991	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
K8U55_RS28980	84272..84976	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2	-	1..131273	131273

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T219206 WP_001372321.1 NZ_CP084707:80117-80242 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T219206 NZ_CP116197:c4284263-4283913 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT219206 NZ_CP084707:c80038-79973 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin