Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4530134..4530712 Replicon chromosome
Accession NC_008786
Organism Verminephrobacter eiseniae EF01-2

Toxin (Protein)


Gene name higB Uniprot ID A1WQD0
Locus tag VEIS_RS20005 Protein ID WP_011811824.1
Coordinates 4530452..4530712 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VEIS_RS20000 Protein ID WP_011811823.1
Coordinates 4530134..4530442 (-) Length 103 a.a.

Genomic Context

VEIS_RS19980VEIS_RS19985VEIS_RS29155VEIS_RS19995VEIS_RS29925VEIS_RS20000VEIS_RS20005VEIS_RS26955VEIS_RS20015VEIS_RS29160VEIS_RS20020VEIS_RS29930
Location: 4525511..4526272 (762 bp)
Type: Others
Protein ID: WP_011811819.1
Location: 4526353..4527087 (735 bp)
Type: Others
Protein ID: WP_011811820.1
Location: 4527336..4527608 (273 bp)
Type: Others
Protein ID: WP_011811821.1
Location: 4527605..4529902 (2298 bp)
Type: Others
Protein ID: WP_011811822.1
Location: 4531160..4531492 (333 bp)
Type: Others
Protein ID: WP_011811825.1
Location: 4530134..4530442 (309 bp)
Type: Antitoxin
Protein ID: WP_011811823.1
Location: 4530452..4530712 (261 bp)
Type: Toxin
Protein ID: WP_011811824.1
Location: 4530654..4530860 (207 bp)
Type: Others
Protein ID: WP_198138085.1
Location: 4531584..4532786 (1203 bp)
Type: Others
Protein ID: WP_011811826.1
Location: 4532836..4532988 (153 bp)
Type: Others
Protein ID: WP_157048605.1
Location: 4532998..4534008 (1011 bp)
Type: Others
Protein ID: WP_011811827.1
Location: 4534084..4534365 (282 bp)
Type: Others
Protein ID: WP_198138086.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VEIS_RS199804525511..4526272+762WP_011811819.1IS110 family transposase-
VEIS_RS199854526353..4527087+735WP_011811820.1GntR family transcriptional regulator-
VEIS_RS291554527336..4527608+273WP_011811821.1hypothetical protein-
VEIS_RS199954527605..4529902+2298WP_011811822.1hypothetical protein-
VEIS_RS200004530134..4530442-309WP_011811823.1HigA family addiction module antidote proteinAntitoxin
VEIS_RS200054530452..4530712-261WP_011811824.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VEIS_RS269554530654..4530860-207WP_198138085.1hypothetical protein-
VEIS_RS299254531160..4531492+333WP_011811825.1hypothetical protein-
VEIS_RS200154531584..4532786-1203WP_011811826.1cystathionine beta-lyase-
VEIS_RS291604532836..4532988-153WP_157048605.1hypothetical protein-
VEIS_RS200204532998..4534008-1011WP_011811827.1tripartite tricarboxylate transporter substrate binding protein-
VEIS_RS299304534084..4534365-282WP_198138086.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(18-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10211.64 Da        Isoelectric Point: 10.5735

>T21920 WP_011811824.1 NC_008786:c4530712-4530452 [Verminephrobacter eiseniae EF01-2]
VTRHEALFRSQCVPRFKNIERVARRKLLQLHAATEWASLRVPPGNRLEALKGDRRGQHSIRIDDQWRVCFVWHDDGARQV
EIVDYH

Download         Length: 261 bp

>T21920 NC_008786:c4530712-4530452 [Verminephrobacter eiseniae EF01-2]
GTGACGCGACACGAGGCGCTTTTCCGCAGCCAGTGTGTGCCCCGGTTCAAGAACATTGAACGTGTGGCACGGCGAAAGCT
CTTGCAACTGCATGCCGCTACTGAATGGGCCAGTTTGCGGGTTCCCCCCGGGAACCGGCTCGAAGCGTTGAAGGGCGACC
GCCGGGGGCAACACAGTATCCGCATCGATGACCAGTGGCGCGTCTGTTTCGTATGGCATGACGACGGTGCCCGCCAGGTC
GAAATCGTGGACTACCACTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11698.55 Da        Isoelectric Point: 6.3274

>AT21920 WP_011811823.1 NC_008786:c4530442-4530134 [Verminephrobacter eiseniae EF01-2]
MAELLDEIHPGEILLEDFMKPMGISARQLAADIDVSPSRISDLVHGNRPITADTALRLGLFFDMEPRFWMNLQTEYDMRV
ATRTVREKIALRIRVFHHHAAA

Download         Length: 309 bp

>AT21920 NC_008786:c4530442-4530134 [Verminephrobacter eiseniae EF01-2]
ATGGCTGAACTACTCGACGAAATCCACCCTGGCGAAATCCTGCTGGAGGACTTCATGAAGCCGATGGGAATATCTGCGCG
CCAGCTTGCGGCAGACATTGACGTCTCACCCAGCCGGATCAGTGATCTGGTGCACGGAAATCGTCCGATCACCGCTGATA
CGGCTTTGCGGCTCGGTTTGTTTTTCGACATGGAGCCGCGATTCTGGATGAATCTGCAAACGGAGTACGACATGCGCGTC
GCGACACGCACCGTGCGCGAAAAAATCGCGCTCAGGATTCGTGTTTTCCATCATCATGCCGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA1WQD0

Antitoxin

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Source
ID
Structure
No matching records found

References