Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1502709..1503355 Replicon chromosome
Accession NZ_CP084705
Organism Klebsiella pneumoniae strain KP1064WHY

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag K8U55_RS07110 Protein ID WP_002920560.1
Coordinates 1502709..1503056 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag K8U55_RS07115 Protein ID WP_002920557.1
Coordinates 1503056..1503355 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8U55_RS07100 (K8U55_07100) 1498635..1500068 + 1434 WP_002920564.1 glycogen synthase GlgA -
K8U55_RS07105 (K8U55_07105) 1500086..1502533 + 2448 WP_002920561.1 glycogen phosphorylase -
K8U55_RS07110 (K8U55_07110) 1502709..1503056 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8U55_RS07115 (K8U55_07115) 1503056..1503355 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
K8U55_RS07120 (K8U55_07120) 1503418..1504926 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
K8U55_RS07125 (K8U55_07125) 1505131..1505460 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
K8U55_RS07130 (K8U55_07130) 1505511..1506341 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
K8U55_RS07135 (K8U55_07135) 1506391..1507149 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T219188 WP_002920560.1 NZ_CP084705:1502709-1503056 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T219188 NZ_CP116197:203371-203478 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT219188 WP_002920557.1 NZ_CP084705:1503056-1503355 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT219188 NZ_CP116197:c203322-203259 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References