Detailed information of TA system TA219180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2884747..2885254
• Replicon: chromosome
• Accession: NZ_CP084704
• Organism: Desulfurispirillum indicum strain A2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LGV61_RS13035
• Protein ID: WP_226508270.1
• Coordinates: 2884994..2885254 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LGV61_RS13030
• Protein ID: WP_226508269.1
• Coordinates: 2884747..2885001 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGV61_RS13005 (LGV61_13000)	2880017..2880376	-	360	WP_264180155.1	FxsA family protein	-
LGV61_RS13010 (LGV61_13005)	2880614..2881348	-	735	WP_226508265.1	hypothetical protein	-
LGV61_RS13015 (LGV61_13010)	2881366..2882088	-	723	WP_226508266.1	hypothetical protein	-
LGV61_RS13020 (LGV61_13015)	2882088..2882522	-	435	WP_226508267.1	hypothetical protein	-
LGV61_RS13025 (LGV61_13020)	2882927..2884093	-	1167	WP_226508268.1	PD-(D/E)XK nuclease family protein	-
LGV61_RS13030 (LGV61_13025)	2884747..2885001	+	255	WP_226508269.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LGV61_RS13035 (LGV61_13030)	2884994..2885254	+	261	WP_226508270.1	Txe/YoeB family addiction module toxin	Toxin
LGV61_RS13040 (LGV61_13035)	2885599..2885811	+	213	WP_226508271.1	hypothetical protein	-
LGV61_RS13045 (LGV61_13040)	2885804..2886091	+	288	WP_226508272.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LGV61_RS13050 (LGV61_13045)	2886517..2887017	+	501	WP_226508273.1	3'-5' exonuclease	-
LGV61_RS13055 (LGV61_13050)	2887021..2887998	+	978	WP_226508274.1	WYL domain-containing protein	-
LGV61_RS13065 (LGV61_13060)	2888332..2889669	+	1338	WP_226508275.1	CHASE2 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2880017..2890572	10555
	-	flank	IS/Tn	-	-	2889735..2890223	488

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9959.34 Da
• Isoelectric Point: 9.7531

>T219180 WP_226508270.1 NZ_CP084704:2884994-2885254 [Desulfurispirillum indicum]
MSSRLLATDEAWSDYLYWQVQDKKTLKRINRLISDTKGSPFAGIGKPEPLKENLAGFWSRRINDTNRLVYAVDNTAITII
SCRYNY

Nucleotide

• Length: 261 bp

>T219180 NZ_CP084704:2884994-2885254 [Desulfurispirillum indicum]
ATGAGTAGCCGCTTGCTGGCAACGGACGAGGCCTGGAGCGACTACCTGTACTGGCAAGTGCAGGACAAAAAGACACTGAA
GCGGATTAACCGGCTCATAAGCGATACCAAGGGATCGCCCTTTGCGGGTATTGGAAAGCCGGAGCCGTTAAAAGAAAACC
TGGCGGGTTTCTGGTCCCGCCGTATTAATGACACCAACCGCCTGGTCTATGCCGTCGATAATACGGCGATTACCATCATC
TCGTGCCGCTACAATTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9308.53 Da
• Isoelectric Point: 7.2004

>AT219180 WP_226508269.1 NZ_CP084704:2884747-2885001 [Desulfurispirillum indicum]
MKVVSFTEARNSLKTLLNSVVNDADTAVITRRDSGNAVVMSLDYYNSLMETVHLLRSPENAAHLNRSIAQYKAGKVTPRD
VVDE

Nucleotide

• Length: 255 bp

>AT219180 NZ_CP084704:2884747-2885001 [Desulfurispirillum indicum]
ATGAAGGTTGTATCTTTTACAGAAGCGAGAAATAGCCTGAAGACGCTGCTGAATTCAGTGGTCAACGACGCAGATACGGC
GGTGATTACGCGTCGCGATTCAGGGAATGCGGTTGTCATGTCGCTTGATTACTACAACAGCCTGATGGAGACGGTGCATC
TGCTGCGCTCGCCGGAAAATGCCGCGCATTTGAACCGCTCGATTGCCCAGTATAAAGCGGGGAAAGTAACGCCACGGGAT
GTGGTGGATGAGTAG