Detailed information of TA system TA219157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 1397949..1398551
• Replicon: chromosome
• Accession: NZ_CP084692
• Organism: Enterobacter mori strain BC01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: K6742_RS06510
• Protein ID: WP_182402094.1
• Coordinates: 1397949..1398260 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A3A3ZDL2
• Locus tag: K6742_RS06515
• Protein ID: WP_061096529.1
• Coordinates: 1398261..1398551 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6742_RS06480 (K6742_06480)	1393056..1393952	+	897	WP_108417976.1	sugar kinase	-
K6742_RS06485 (K6742_06485)	1393987..1394787	+	801	WP_032639926.1	DeoR/GlpR family DNA-binding transcription regulator	-
K6742_RS06490 (K6742_06490)	1394907..1395506	+	600	WP_214595030.1	glucose-1-phosphatase	-
K6742_RS06495 (K6742_06495)	1395500..1396381	+	882	WP_010436837.1	virulence factor BrkB family protein	-
K6742_RS06500 (K6742_06500)	1396378..1396815	+	438	WP_108417975.1	D-aminoacyl-tRNA deacylase	-
K6742_RS06505 (K6742_06505)	1396860..1397801	+	942	WP_010436842.1	fatty acid biosynthesis protein FabY	-
K6742_RS06510 (K6742_06510)	1397949..1398260	+	312	WP_182402094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6742_RS06515 (K6742_06515)	1398261..1398551	+	291	WP_061096529.1	NadS family protein	Antitoxin
K6742_RS06520 (K6742_06520)	1398594..1399523	-	930	WP_010436850.1	formate dehydrogenase accessory protein FdhE	-
K6742_RS06525 (K6742_06525)	1399520..1400155	-	636	WP_010436852.1	formate dehydrogenase cytochrome b556 subunit	-
K6742_RS06530 (K6742_06530)	1400152..1401054	-	903	WP_010436855.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12206.19 Da
• Isoelectric Point: 9.7548

>T219157 WP_182402094.1 NZ_CP084692:1397949-1398260 [Enterobacter mori]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDLIQNTGGLRKIRWLAGGKGKRGGVRVIYFHRTREFEIRLLLIY
RKGIKDDLSASEKAILKKMIERW

Nucleotide

• Length: 312 bp

>T219157 NZ_CP116191:c3762801-3762394 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10721.29 Da
• Isoelectric Point: 10.7588

>AT219157 WP_061096529.1 NZ_CP084692:1398261-1398551 [Enterobacter mori]
MDKALFERLTQSMAQMNEIAEGKREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Nucleotide

• Length: 291 bp

>AT219157 NZ_CP116191:c3763048-3762782 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3A3ZDL2