219140

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1389945..1390638 Replicon chromosome
Accession NZ_CP084683
Organism Escherichia coli strain BL21(RP)

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LGS58_RS06850 Protein ID WP_000415584.1
Coordinates 1390342..1390638 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LGS58_RS06845 Protein ID WP_000650107.1
Coordinates 1389945..1390340 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGS58_RS06835 (1385809) 1385809..1388067 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
LGS58_RS06840 (1388205) 1388205..1389812 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LGS58_RS06845 (1389945) 1389945..1390340 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LGS58_RS06850 (1390342) 1390342..1390638 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LGS58_RS06855 (1390843) 1390843..1391325 - 483 WP_000183505.1 GyrI-like domain-containing protein -
LGS58_RS06860 (1391378) 1391378..1391770 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LGS58_RS06865 (1391922) 1391922..1392581 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LGS58_RS06870 (1392578) 1392578..1393927 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LGS58_RS06875 (1393973) 1393973..1394305 - 333 WP_000917684.1 DUF2645 family protein -
LGS58_RS06880 (1394624) 1394624..1395205 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
LGS58_RS06885 (1395236) 1395236..1395550 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T219140 WP_000415584.1 NZ_CP084683:c1390638-1390342 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T219140 NZ_CP116188:c4427176-4427003 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT219140 WP_000650107.1 NZ_CP084683:c1390340-1389945 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT219140 NZ_CP116188:c4427500-4427204 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References