Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1932994..1933651 Replicon chromosome
Accession NZ_CP084655
Organism Pectobacterium brasiliense strain SR10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGL97_RS08635 Protein ID WP_039320151.1
Coordinates 1933280..1933651 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A433N287
Locus tag LGL97_RS08630 Protein ID WP_010281167.1
Coordinates 1932994..1933293 (-) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL97_RS08610 (LGL97_08610) 1928265..1929236 + 972 WP_010281174.1 nucleoside hydrolase -
LGL97_RS08615 (LGL97_08615) 1929236..1930213 + 978 WP_039317548.1 ABC transporter permease -
LGL97_RS08620 (LGL97_08620) 1930210..1931118 + 909 WP_052903988.1 ABC transporter permease -
LGL97_RS08625 (LGL97_08625) 1931158..1932957 + 1800 WP_225583739.1 ABC transporter ATP-binding protein -
LGL97_RS08630 (LGL97_08630) 1932994..1933293 - 300 WP_010281167.1 XRE family transcriptional regulator Antitoxin
LGL97_RS08635 (LGL97_08635) 1933280..1933651 - 372 WP_039320151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL97_RS08640 (LGL97_08640) 1933989..1934687 + 699 WP_225583813.1 D-galactonate utilization transcriptional regulator DgoR -
LGL97_RS08645 (LGL97_08645) 1934684..1935580 + 897 WP_225583738.1 2-dehydro-3-deoxygalactonokinase -
LGL97_RS08650 (LGL97_08650) 1935564..1936181 + 618 WP_010281152.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
LGL97_RS08655 (LGL97_08655) 1936178..1937326 + 1149 WP_010281150.1 galactonate dehydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(14-108)

Antitoxin

(32-80)


Sequences


Toxin        


Download         Length: 124 a.a.        Molecular weight: 14145.07 Da        Isoelectric Point: 4.7254

>T219084 WP_039320151.1 NZ_CP084655:c1933651-1933280 [Pectobacterium brasiliense]
MAWEIVTRALFDTWFDEQTETVQEEVLAHLVILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFDRTRKA
IVLCAGDKKGEDEKLFYERMIKIADAEFASHLISPEVKEDGDA

Download         Length: 372 bp

>T219084 NZ_CP116176:c2839532-2839281 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11048.08 Da        Isoelectric Point: 10.6442

>AT219084 WP_010281167.1 NZ_CP084655:c1933293-1932994 [Pectobacterium brasiliense]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT219084 NZ_CP116176:c2839284-2839030 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A433N287

References