Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 50831..51491 Replicon chromosome
Accession NZ_CP084655
Organism Pectobacterium brasiliense strain SR10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGL97_RS00230 Protein ID WP_010284411.1
Coordinates 51138..51491 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGL97_RS00225 Protein ID WP_119874427.1
Coordinates 50831..51133 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL97_RS00200 (LGL97_00200) 45953..47389 - 1437 WP_225582492.1 glycoside hydrolase family 1 protein -
LGL97_RS00205 (LGL97_00205) 47593..48048 - 456 WP_225582491.1 helix-turn-helix domain-containing protein -
LGL97_RS00210 (LGL97_00210) 48115..49371 + 1257 WP_225582490.1 MFS transporter -
LGL97_RS00215 (LGL97_00215) 49386..49736 - 351 WP_225582489.1 metalloregulator ArsR/SmtB family transcription factor -
LGL97_RS00220 (LGL97_00220) 49789..50793 + 1005 WP_225582488.1 threonine/serine dehydratase -
LGL97_RS00225 (LGL97_00225) 50831..51133 - 303 WP_119874427.1 helix-turn-helix transcriptional regulator Antitoxin
LGL97_RS00230 (LGL97_00230) 51138..51491 - 354 WP_010284411.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL97_RS00235 (LGL97_00235) 51930..52769 + 840 WP_010284408.1 glutathione-dependent disulfide-bond oxidoreductase -
LGL97_RS00240 (LGL97_00240) 52829..54073 - 1245 WP_225582487.1 multidrug effflux MFS transporter -
LGL97_RS00245 (LGL97_00245) 54200..55456 + 1257 WP_225582486.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13475.49 Da        Isoelectric Point: 9.8932

>T219075 WP_010284411.1 NZ_CP084655:c51491-51138 [Pectobacterium brasiliense]
VWKIETTDVFDSWFSTLNDRDRAYVLAALIVLREKGPMLSRPYADTVKGSRYSNMKELRIQSGGMPIRAFFAFDPHRTGI
LLCAGNKSGNEKRFYDEMIPLADREFTTYLKKSEKKG

Download         Length: 354 bp

>T219075 NZ_CP116176:c830932-830654 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11107.90 Da        Isoelectric Point: 6.2283

>AT219075 WP_119874427.1 NZ_CP084655:c51133-50831 [Pectobacterium brasiliense]
MGRTLEQLIADEKPDVVVEAHAIAADMLLNIHLAELRERVQKTQVEMAQVLGLKQPTIAGMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYGFTL

Download         Length: 303 bp

>AT219075 NZ_CP116176:c831195-830935 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References