Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3162844..3163504 Replicon chromosome
Accession NZ_CP084654
Organism Pectobacterium versatile strain SR12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGL95_RS14135 Protein ID WP_103862013.1
Coordinates 3163151..3163504 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGL95_RS14130 Protein ID WP_010298722.1
Coordinates 3162844..3163146 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL95_RS14100 (LGL95_14100) 3159072..3159665 + 594 WP_103941190.1 flavodoxin -
LGL95_RS14105 (LGL95_14105) 3159733..3160368 - 636 WP_103862009.1 NAD(P)H-binding protein -
LGL95_RS14110 (LGL95_14110) 3160488..3160913 - 426 WP_103862010.1 DoxX family protein -
LGL95_RS14115 (LGL95_14115) 3160991..3161395 + 405 WP_205076552.1 helix-turn-helix domain-containing protein -
LGL95_RS14120 (LGL95_14120) 3161411..3161749 - 339 WP_103862011.1 metalloregulator ArsR/SmtB family transcription factor -
LGL95_RS14125 (LGL95_14125) 3161802..3162806 + 1005 WP_103862012.1 threonine/serine dehydratase -
LGL95_RS14130 (LGL95_14130) 3162844..3163146 - 303 WP_010298722.1 XRE family transcriptional regulator Antitoxin
LGL95_RS14135 (LGL95_14135) 3163151..3163504 - 354 WP_103862013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL95_RS14140 (LGL95_14140) 3163718..3164158 - 441 WP_103862014.1 helix-turn-helix domain-containing protein -
LGL95_RS14145 (LGL95_14145) 3164261..3164872 + 612 WP_103862015.1 NAD(P)-dependent oxidoreductase -
LGL95_RS14150 (LGL95_14150) 3165037..3165876 + 840 WP_103862016.1 glutathione-dependent disulfide-bond oxidoreductase -
LGL95_RS14155 (LGL95_14155) 3165992..3166963 - 972 WP_103862019.1 chemotaxis protein -
LGL95_RS14160 (LGL95_14160) 3167504..3168166 + 663 WP_103941176.1 DUF3313 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13510.52 Da        Isoelectric Point: 9.4984

>T219058 WP_103862013.1 NZ_CP084654:c3163504-3163151 [Pectobacterium versatile]
VWRIETTDVFDGWFSALNDRDRACVLAALIVLREKGPMLSRPYADMVKGSRYSNMKELRIQSGGTPIRAFFAFDPHRTGI
LLCAGNKSGNEKRFYDEMLPFAERELTNYLKKSEKRE

Download         Length: 354 bp

>T219058 NZ_CP116169:1999659-1999762 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11282.16 Da        Isoelectric Point: 5.6573

>AT219058 WP_010298722.1 NZ_CP084654:c3163146-3162844 [Pectobacterium versatile]
MGRTLEQLLADEKPEVVVDAHAIATEMLLNIHLAELRERVQKTQVEMAQVLGLKQPTVAVMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYEFML

Download         Length: 303 bp

>AT219058 NZ_CP116169:c1999800-1999529 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References