Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1501504..1502111 Replicon chromosome
Accession NZ_CP084625
Organism Pseudomonas lalkuanensis strain ACYW.190

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LF844_RS07150 Protein ID WP_120649741.1
Coordinates 1501504..1501818 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LF844_RS07155 Protein ID WP_120649742.1
Coordinates 1501824..1502111 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LF844_RS07125 (LF844_07125) 1497226..1497564 + 339 WP_226283727.1 DUF2523 family protein -
LF844_RS07130 (LF844_07130) 1497565..1498677 + 1113 WP_226283728.1 zonular occludens toxin domain-containing protein -
LF844_RS07135 (LF844_07135) 1498687..1498989 + 303 WP_226283729.1 hypothetical protein -
LF844_RS07140 (LF844_07140) 1499176..1500453 + 1278 WP_226283730.1 hypothetical protein -
LF844_RS07145 (LF844_07145) 1500453..1501460 + 1008 WP_226283731.1 tyrosine-type recombinase/integrase -
LF844_RS07150 (LF844_07150) 1501504..1501818 + 315 WP_120649741.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LF844_RS07155 (LF844_07155) 1501824..1502111 + 288 WP_120649742.1 NadS family protein Antitoxin
LF844_RS07165 (LF844_07165) 1502376..1503257 - 882 WP_151132341.1 alpha/beta hydrolase -
LF844_RS07170 (LF844_07170) 1503656..1504348 - 693 WP_226283732.1 pseudouridine synthase -
LF844_RS07175 (LF844_07175) 1504348..1504560 - 213 WP_226283733.1 cysteine-rich CWC family protein -
LF844_RS07180 (LF844_07180) 1504824..1505546 + 723 WP_151132344.1 CDP-alcohol phosphatidyltransferase family protein -
LF844_RS07185 (LF844_07185) 1505737..1506177 + 441 WP_151132345.1 carboxymuconolactone decarboxylase family protein -
LF844_RS07190 (LF844_07190) 1506185..1506601 + 417 WP_151132346.1 cupin domain-containing protein -
LF844_RS07195 (LF844_07195) 1506840..1507049 + 210 WP_151132347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11895.67 Da        Isoelectric Point: 10.0550

>T218907 WP_120649741.1 NZ_CP084625:1501504-1501818 [Pseudomonas lalkuanensis]
MIFIETPIFTKRLRELLSDDSYAAFQRQLAERPDMGDVIEGTGGIRKVRVASGGHGKRGGSRVIYYHFTSASQIALLLIY
PKNEKDDLSADERKVLKQIIERWR

Download         Length: 315 bp

>T218907 NZ_CP116123:2873809-2873916 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10862.45 Da        Isoelectric Point: 10.0108

>AT218907 WP_120649742.1 NZ_CP084625:1501824-1502111 [Pseudomonas lalkuanensis]
MSKFFEDLLESVQQMDEIHRGERKPSREFTVDALQVKEIRKATGLTQAKFAAMIDVQLGTLRNWEQGRREPTGPAKALLR
AIHNDPKHVIQALSH

Download         Length: 288 bp

>AT218907 NZ_CP116123:c2873762-2873696 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References