218875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1021055..1021755 Replicon chromosome
Accession NZ_CP084582
Organism Micromonospora aurantiaca strain G9

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag LF814_RS05105 Protein ID WP_191971141.1
Coordinates 1021055..1021447 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag LF814_RS05110 Protein ID WP_151012235.1
Coordinates 1021444..1021755 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LF814_RS05085 (LF814_05090) 1016551..1017384 + 834 WP_013284170.1 ABC transporter permease -
LF814_RS05090 (LF814_05095) 1017381..1018802 + 1422 WP_151012241.1 FAD-dependent oxidoreductase -
LF814_RS05095 (LF814_05100) 1018802..1020004 + 1203 WP_151012239.1 saccharopine dehydrogenase C-terminal domain-containing protein -
LF814_RS05100 (LF814_05105) 1020001..1021014 + 1014 WP_151012237.1 agmatinase -
LF814_RS05105 (LF814_05110) 1021055..1021447 + 393 WP_191971141.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LF814_RS05110 (LF814_05115) 1021444..1021755 + 312 WP_151012235.1 XRE family transcriptional regulator Antitoxin
LF814_RS05115 (LF814_05120) 1021775..1022224 - 450 WP_151012233.1 hypothetical protein -
LF814_RS05120 (LF814_05125) 1022326..1022673 - 348 WP_013284177.1 DUF779 domain-containing protein -
LF814_RS05125 (LF814_05130) 1022673..1024178 - 1506 WP_013284178.1 aldehyde dehydrogenase family protein -
LF814_RS05130 (LF814_05135) 1024219..1025502 - 1284 WP_151012231.1 transcriptional regulator -
LF814_RS05135 (LF814_05140) 1025740..1026405 + 666 WP_030271171.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-117)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-91)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14860.87 Da        Isoelectric Point: 10.7236

>T218875 WP_191971141.1 NZ_CP084582:1021055-1021447 [Micromonospora aurantiaca]
MGADGKRWSVRVTGEVRHWLRDLRDHDPSSYESVRVAVDKLAEVGPGLGRPLVDTLRGSSLRNLKELRPRSGRDVAIRVL
FVFDPWSQAVLLVAGNKAGNWTRWYRQHIPAAEVAYKVWLDSERERRGES

Download         Length: 393 bp

>T218875 NZ_CP116115:c1219609-1219391 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11610.86 Da        Isoelectric Point: 4.4698

>AT218875 WP_151012235.1 NZ_CP084582:1021444-1021755 [Micromonospora aurantiaca]
VTEFYHWDAVRAELGGDDEAYEAERARTDAWVSAFHLAEERKRLGLTQRQVAEIMGVTPGRVSQIENGDLDVNEVATLSR
YANALGARLRIIFDYGDDLRQIA

Download         Length: 312 bp

>AT218875 NZ_CP116115:c1220009-1219635 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References