Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1603224..1603809 Replicon chromosome
Accession NZ_CP084578
Organism Sulfurimonas sp. SWIR-19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LCX93_RS08335 Protein ID WP_226065876.1
Coordinates 1603525..1603809 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LCX93_RS08330 Protein ID WP_193150127.1
Coordinates 1603224..1603514 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCX93_RS08300 (LCX93_08300) 1598478..1598966 + 489 WP_226065871.1 hypothetical protein -
LCX93_RS08305 (LCX93_08305) 1598970..1600235 + 1266 WP_226065872.1 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase -
LCX93_RS08310 (LCX93_08310) 1600287..1601393 + 1107 WP_226065873.1 homoserine O-acetyltransferase -
LCX93_RS08315 (LCX93_08315) 1601386..1601574 + 189 WP_151899980.1 exodeoxyribonuclease VII small subunit -
LCX93_RS08320 (LCX93_08320) 1601571..1602386 + 816 WP_226065874.1 carbon-nitrogen hydrolase family protein -
LCX93_RS08325 (LCX93_08325) 1602386..1603060 + 675 WP_226065875.1 ThiF family adenylyltransferase -
LCX93_RS08330 (LCX93_08330) 1603224..1603514 - 291 WP_193150127.1 HigA family addiction module antitoxin Antitoxin
LCX93_RS08335 (LCX93_08335) 1603525..1603809 - 285 WP_226065876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCX93_RS08345 (LCX93_08345) 1604055..1604492 - 438 WP_226065877.1 globin -
LCX93_RS08350 (LCX93_08350) 1604495..1607596 - 3102 WP_226065878.1 efflux RND transporter permease subunit -
LCX93_RS08355 (LCX93_08355) 1607606..1607884 - 279 WP_151899975.1 hypothetical protein -
LCX93_RS08360 (LCX93_08360) 1607881..1608807 - 927 WP_226065879.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11146.80 Da        Isoelectric Point: 9.7915

>T218872 WP_226065876.1 NZ_CP084578:c1603809-1603525 [Sulfurimonas sp. SWIR-19]
MIQSFKCKYTKQLFNGKYQKKFSQAVNNIGKRKLDMLDAAFALEDLKVPPSNHLEQLQGDLKGFYSIRINNQFRLIFKFE
NSNAYDIYIDDYHK

Download         Length: 285 bp

>T218872 NZ_CP116115:c693065-692913 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11151.02 Da        Isoelectric Point: 10.0224

>AT218872 WP_193150127.1 NZ_CP084578:c1603514-1603224 [Sulfurimonas sp. SWIR-19]
MKEIRPSTHPGIILKEEFALPLNLTQAKLSKDLKVGIKTLSELYNEKRGITPLMALKLSEYFGTTPQFWLNLQNAYDLYK
TYQKQKENLKEIHRAA

Download         Length: 291 bp

>AT218872 NZ_CP116115:693114-693171 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References