Detailed information of TA system TA218827

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443962..2444187
• Replicon: chromosome
• Accession: NZ_CP084532
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain SE211

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LDP70_RS11890
• Protein ID: WP_000813254.1
• Coordinates: 2443962..2444117 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2444129..2444187 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDP70_RS11855	2439069..2439350	-	282	WP_000445513.1	phage holin family protein	-
LDP70_RS11860	2439340..2439528	-	189	WP_001688615.1	putative holin	-
LDP70_RS11865	2439522..2439845	-	324	Protein_2323	tellurite/colicin resistance protein	-
LDP70_RS11870	2442016..2442552	-	537	WP_000640113.1	DUF1133 family protein	-
LDP70_RS11875	2442549..2442839	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LDP70_RS11880	2442839..2443438	-	600	WP_000940751.1	DUF1367 family protein	-
LDP70_RS11885	2443501..2443671	-	171	WP_000734094.1	hypothetical protein	-
LDP70_RS11890	2443962..2444117	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2444129..2444187	+	59	-	-	Antitoxin
LDP70_RS11895	2444544..2445476	+	933	WP_000556390.1	hypothetical protein	-
LDP70_RS11900	2445473..2446027	+	555	WP_001033796.1	hypothetical protein	-
LDP70_RS11905	2446189..2446518	-	330	WP_001676916.1	DUF977 family protein	-
LDP70_RS23130	2446562..2446609	-	48	Protein_2332	hypothetical protein	-
LDP70_RS11915	2446791..2447258	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LDP70_RS11920	2447643..2447798	+	156	WP_085981757.1	DUF1391 family protein	-
LDP70_RS11925	2447906..2448427	-	522	WP_000004762.1	super-infection exclusion protein B	-
LDP70_RS11930	2448865..2449086	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438527..2450398	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T218827 WP_000813254.1 NZ_CP084532:c2444117-2443962 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T218827 NZ_CP116106:c2529329-2529153 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT218827 NZ_CP084532:2444129-2444187 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin