Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3557067..3557760 Replicon chromosome
Accession NZ_CP084529
Organism Escherichia coli strain Origami2-DE3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LFW28_RS16950 Protein ID WP_000415584.1
Coordinates 3557067..3557363 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LFW28_RS16955 Protein ID WP_000650107.1
Coordinates 3557365..3557760 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFW28_RS16915 (3552155) 3552155..3552469 - 315 WP_000958598.1 putative quinol monooxygenase -
LFW28_RS16920 (3552500) 3552500..3553081 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LFW28_RS16925 (3553400) 3553400..3553732 + 333 WP_000917684.1 DUF2645 family protein -
LFW28_RS16930 (3553778) 3553778..3555127 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LFW28_RS16935 (3555124) 3555124..3555783 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
LFW28_RS16940 (3555935) 3555935..3556327 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LFW28_RS16945 (3556380) 3556380..3556862 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LFW28_RS16950 (3557067) 3557067..3557363 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LFW28_RS16955 (3557365) 3557365..3557760 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LFW28_RS16960 (3557893) 3557893..3559500 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LFW28_RS16965 (3559638) 3559638..3561896 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T218808 WP_000415584.1 NZ_CP084529:3557067-3557363 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T218808 NZ_CP116103:c2839972-2839718 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT218808 WP_000650107.1 NZ_CP084529:3557365-3557760 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT218808 NZ_CP116103:c2840220-2839969 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References