Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1944661..1945336 | Replicon | chromosome |
| Accession | NZ_CP084524 | ||
| Organism | Edwardsiella ictaluri strain S97-773 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | DB731_RS09145 | Protein ID | WP_233420345.1 |
| Coordinates | 1944661..1945038 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | C5BBM8 |
| Locus tag | DB731_RS09150 | Protein ID | WP_015871333.1 |
| Coordinates | 1945028..1945336 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DB731_RS09105 (DB731_09090) | 1939933..1940484 | - | 552 | WP_015871324.1 | putative peptidoglycan-binding domain-containing protein | - |
| DB731_RS09110 (DB731_09095) | 1940487..1940834 | - | 348 | WP_035608895.1 | phage holin, lambda family | - |
| DB731_RS09115 (DB731_09100) | 1940918..1941247 | - | 330 | WP_015871326.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| DB731_RS09120 (DB731_09105) | 1941222..1941452 | - | 231 | WP_015871327.1 | ParD-like family protein | - |
| DB731_RS09125 (DB731_09110) | 1941584..1941828 | - | 245 | Protein_1759 | transposase | - |
| DB731_RS09130 (DB731_09115) | 1941934..1942752 | - | 819 | WP_015871329.1 | hypothetical protein | - |
| DB731_RS09135 (DB731_09120) | 1942841..1943356 | - | 516 | WP_034165088.1 | hypothetical protein | - |
| DB731_RS09140 (DB731_09125) | 1943478..1944260 | - | 783 | WP_015871331.1 | Rha family transcriptional regulator | - |
| DB731_RS09145 (DB731_09130) | 1944661..1945038 | + | 378 | WP_233420345.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DB731_RS09150 (DB731_09135) | 1945028..1945336 | + | 309 | WP_015871333.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| DB731_RS09155 (DB731_09140) | 1945457..1945951 | + | 495 | WP_256594327.1 | transcriptional regulator | - |
| DB731_RS09160 (DB731_09145) | 1946318..1946827 | - | 510 | WP_071525693.1 | hypothetical protein | - |
| DB731_RS09165 (DB731_09150) | 1946828..1947868 | - | 1041 | WP_015871335.1 | hypothetical protein | - |
| DB731_RS09170 (DB731_09155) | 1948013..1948312 | - | 300 | WP_015871336.1 | DUF1364 family protein | - |
| DB731_RS09175 (DB731_09160) | 1948315..1948959 | - | 645 | WP_015871337.1 | DUF1367 family protein | - |
| DB731_RS09180 (DB731_09165) | 1949069..1949416 | - | 348 | WP_015871339.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1905553..1974052 | 68499 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14680.05 Da Isoelectric Point: 10.1221
>T218770 WP_233420345.1 NZ_CP084524:1944661-1945038 [Edwardsiella ictaluri]
MGKNLRKHNNIVMFHSMNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGI
ARVFYCTLTGKRIVMLHSFIKKTQKTPSAERKKAETRMKEVKHGW
MGKNLRKHNNIVMFHSMNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGI
ARVFYCTLTGKRIVMLHSFIKKTQKTPSAERKKAETRMKEVKHGW
Download Length: 378 bp
>T218770 NZ_CP116100:109705-109956 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11207.86 Da Isoelectric Point: 8.5371
>AT218770 WP_015871333.1 NZ_CP084524:1945028-1945336 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
Download Length: 309 bp
>AT218770 NZ_CP116100:109953-110207 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|