Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1947913..1948540 Replicon chromosome
Accession NZ_CP084521
Organism Edwardsiella ictaluri strain S07-698

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag DB741_RS09170 Protein ID WP_015871332.1
Coordinates 1947913..1948242 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C5BBM8
Locus tag DB741_RS09175 Protein ID WP_015871333.1
Coordinates 1948232..1948540 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DB741_RS09130 (DB741_09130) 1943137..1943688 - 552 WP_015871324.1 putative peptidoglycan-binding domain-containing protein -
DB741_RS09135 (DB741_09135) 1943691..1944038 - 348 WP_035608895.1 phage holin, lambda family -
DB741_RS09140 (DB741_09140) 1944122..1944451 - 330 WP_015871326.1 type II toxin-antitoxin system RelE/ParE family toxin -
DB741_RS09145 (DB741_09145) 1944426..1944656 - 231 WP_015871327.1 ParD-like family protein -
DB741_RS09150 (DB741_09150) 1944788..1945032 - 245 Protein_1761 transposase -
DB741_RS09155 (DB741_09155) 1945138..1945956 - 819 WP_015871329.1 hypothetical protein -
DB741_RS09160 (DB741_09160) 1946045..1946560 - 516 WP_034165088.1 hypothetical protein -
DB741_RS09165 (DB741_09165) 1946682..1947464 - 783 WP_015871331.1 Rha family transcriptional regulator -
DB741_RS09170 (DB741_09170) 1947913..1948242 + 330 WP_015871332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DB741_RS09175 (DB741_09175) 1948232..1948540 + 309 WP_015871333.1 helix-turn-helix transcriptional regulator Antitoxin
DB741_RS09180 (DB741_09180) 1948661..1949155 + 495 WP_256594327.1 transcriptional regulator -
DB741_RS09185 (DB741_09185) 1949522..1950031 - 510 WP_071525693.1 hypothetical protein -
DB741_RS09190 (DB741_09190) 1950032..1951072 - 1041 WP_015871335.1 hypothetical protein -
DB741_RS09195 (DB741_09195) 1951217..1951516 - 300 WP_015871336.1 DUF1364 family protein -
DB741_RS09200 (DB741_09200) 1951519..1952163 - 645 WP_015871337.1 DUF1367 family protein -
DB741_RS09205 (DB741_09205) 1952273..1952620 - 348 WP_015871339.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1908871..1972960 64089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T218764 WP_015871332.1 NZ_CP084521:1947913-1948242 [Edwardsiella ictaluri]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T218764 NZ_CP116094:c4058669-4058355 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11207.86 Da        Isoelectric Point: 8.5371

>AT218764 WP_015871333.1 NZ_CP084521:1948232-1948540 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT218764 NZ_CP116094:c4058358-4057942 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H7J1

Antitoxin

Source ID Structure
AlphaFold DB C5BBM8

References