218697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 742517..743292 Replicon chromosome
Accession NZ_CP084497
Organism Klebsiella pneumoniae strain 1632

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag LDL62_RS03710 Protein ID WP_004150910.1
Coordinates 742807..743292 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LDL62_RS03705 Protein ID WP_004150912.1
Coordinates 742517..742810 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL62_RS03685 (LDL62_03685) 737725..738327 - 603 WP_062954968.1 short chain dehydrogenase -
LDL62_RS03690 (LDL62_03690) 738425..739336 + 912 WP_004188550.1 LysR family transcriptional regulator -
LDL62_RS03695 (LDL62_03695) 739337..740485 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
LDL62_RS03700 (LDL62_03700) 740496..741872 - 1377 WP_004217775.1 cystathionine beta-synthase -
LDL62_RS03705 (LDL62_03705) 742517..742810 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LDL62_RS03710 (LDL62_03710) 742807..743292 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
LDL62_RS03715 (LDL62_03715) 743996..744589 + 594 WP_004188553.1 hypothetical protein -
LDL62_RS03720 (LDL62_03720) 744686..744902 + 217 Protein_731 transposase -
LDL62_RS03725 (LDL62_03725) 745508..746380 + 873 WP_004188557.1 ParA family protein -
LDL62_RS03730 (LDL62_03730) 746380..746763 + 384 WP_004150906.1 hypothetical protein -
LDL62_RS03735 (LDL62_03735) 746756..748123 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 744686..744838 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T218697 WP_004150910.1 NZ_CP084497:742807-743292 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T218697 NZ_CP116085:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT218697 WP_004150912.1 NZ_CP084497:742517-742810 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT218697 NZ_CP116085:c188009-187943 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References