Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1654994..1655621 Replicon chromosome
Accession NZ_CP084432
Organism Edwardsiella tarda strain AL98-87

Toxin (Protein)


Gene name higB Uniprot ID A0A2A7U6J2
Locus tag DCF75_RS07630 Protein ID WP_005294220.1
Coordinates 1655292..1655621 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DCF75_RS07625 Protein ID WP_005286394.1
Coordinates 1654994..1655302 (-) Length 103 a.a.

Genomic Context

DCF75_RS07595DCF75_RS07600DCF75_RS07605DCF75_RS07610DCF75_RS07615DCF75_RS07635DCF75_RS07650DCF75_RS07655DCF75_RS07660DCF75_RS07620DCF75_RS07625DCF75_RS07630DCF75_RS07640DCF75_RS07645
Location: 1650407..1651789 (1383 bp)
Type: Others
Protein ID: WP_005286412.1
Location: 1651817..1652164 (348 bp)
Type: Others
Protein ID: WP_098143178.1
Location: 1652274..1652918 (645 bp)
Type: Others
Protein ID: WP_116605177.1
Location: 1652921..1653223 (303 bp)
Type: Others
Protein ID: WP_116605176.1
Location: 1653315..1654010 (696 bp)
Type: Others
Protein ID: WP_116605175.1
Location: 1656069..1656851 (783 bp)
Type: Others
Protein ID: WP_116605686.1
Location: 1658680..1659303 (624 bp)
Type: Others
Protein ID: WP_226086041.1
Location: 1659668..1660015 (348 bp)
Type: Others
Protein ID: WP_116605688.1
Location: 1660018..1660569 (552 bp)
Type: Others
Protein ID: WP_097364620.1
Location: 1654387..1654899 (513 bp)
Type: Others
Protein ID: WP_226086039.1
Location: 1654994..1655302 (309 bp)
Type: Antitoxin
Protein ID: WP_005286394.1
Location: 1655292..1655621 (330 bp)
Type: Toxin
Protein ID: WP_005294220.1
Location: 1657071..1657418 (348 bp)
Type: Others
Protein ID: WP_116605684.1
Location: 1657418..1658395 (978 bp)
Type: Others
Protein ID: WP_116605682.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DCF75_RS07595 (DCF75_07595)1650407..1651789+1383WP_005286412.1replicative DNA helicase-
DCF75_RS07600 (DCF75_07600)1651817..1652164+348WP_098143178.1hypothetical protein-
DCF75_RS07605 (DCF75_07605)1652274..1652918+645WP_116605177.1DUF1367 family protein-
DCF75_RS07610 (DCF75_07610)1652921..1653223+303WP_116605176.1DUF1364 family protein-
DCF75_RS07615 (DCF75_07615)1653315..1654010+696WP_116605175.1hypothetical protein-
DCF75_RS07620 (DCF75_07620)1654387..1654899-513WP_226086039.1DUF2442 domain-containing protein-
DCF75_RS07625 (DCF75_07625)1654994..1655302-309WP_005286394.1helix-turn-helix transcriptional regulatorAntitoxin
DCF75_RS07630 (DCF75_07630)1655292..1655621-330WP_005294220.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DCF75_RS07635 (DCF75_07635)1656069..1656851+783WP_116605686.1Rha family transcriptional regulator-
DCF75_RS07640 (DCF75_07640)1657071..1657418-348WP_116605684.1STAS-like domain-containing protein-
DCF75_RS07645 (DCF75_07645)1657418..1658395-978WP_116605682.1hypothetical protein-
DCF75_RS07650 (DCF75_07650)1658680..1659303+624WP_226086041.1hypothetical protein-
DCF75_RS07655 (DCF75_07655)1659668..1660015+348WP_116605688.1phage holin, lambda family-
DCF75_RS07660 (DCF75_07660)1660018..1660569+552WP_097364620.1putative peptidoglycan-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1624135..167869754562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12799.83 Da        Isoelectric Point: 9.8421

>T218601 WP_005294220.1 NZ_CP084432:c1655621-1655292 [Edwardsiella tarda]
MNYTIEYYSEEVRLEVDRLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T218601 NZ_CP116046:c960022-959919 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11233.90 Da        Isoelectric Point: 8.5371

>AT218601 WP_005286394.1 NZ_CP084432:c1655302-1654994 [Edwardsiella tarda]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT218601 NZ_CP116046:959881-960152 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2A7U6J2

Antitoxin

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Source
ID
Structure
No matching records found

References