Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 36892..37472 Replicon plasmid pCFD-2-1
Accession NZ_CP084407
Organism Sphingobium sp. CFD-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDB29_RS25525 Protein ID WP_257558321.1
Coordinates 37191..37472 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LDB29_RS25520 Protein ID WP_257558318.1
Coordinates 36892..37179 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB29_RS25500 32950..34431 + 1482 WP_257558314.1 SulP family inorganic anion transporter -
LDB29_RS25505 34772..35810 - 1039 Protein_23 IS110 family transposase -
LDB29_RS25510 35999..36328 - 330 WP_257558316.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDB29_RS25515 36325..36558 - 234 WP_257558509.1 ribbon-helix-helix domain-containing protein -
LDB29_RS25520 36892..37179 - 288 WP_257558318.1 HigA family addiction module antitoxin Antitoxin
LDB29_RS25525 37191..37472 - 282 WP_257558321.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDB29_RS25530 37854..38102 + 249 WP_013848646.1 type II toxin-antitoxin system ParD family antitoxin -
LDB29_RS25535 38099..38404 + 306 WP_257558325.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDB29_RS25540 38502..39098 - 597 WP_257558326.1 hypothetical protein -
LDB29_RS25545 39117..41408 - 2292 WP_257558327.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..360439 360439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10593.07 Da        Isoelectric Point: 7.1665

>T218525 WP_257558321.1 NZ_CP084407:c37472-37191 [Sphingobium sp. CFD-2]
MIQRAKGKLVEQVLVGKPGKGFPDDFFRAAVRKLAMFEAAVNLDDLRSPPGNRLEALSDDRAGQHSIRINDQWRICFVWT
DRGPQDVEIVDYH

Download         Length: 282 bp

>T218525 NZ_CP116026:970854-971204 [Enterococcus casseliflavus]
ATGGTAAGAAAACCTAGACAAGGGGATATTTTGTTATTGGATACAGCTCCTCGTGCTGGACATGAACAAACGGGAAAAAG
GCCCTATATTGTTTTAAGTCATGACATGATTGCAGATTATAGTAACGTTGCCACCGTTGCTCCGATTTCTAGTACAAGTA
GAAACTATCCGTTATATGTAAGTATTAATCCAGATTATGGCATGAAGACAACAGGAAAAGTATTGTTGGATCAATTAACG
ACAATTGATTATGAAGCCAGCGCATGTGTTTTTTTGGAAAAAGCGCATGAGCACTTGGTTGATGAGTTATTGATGAAAGT
TAGAACAGTATTTCAAAAAGTAAGTAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10773.55 Da        Isoelectric Point: 6.6405

>AT218525 WP_257558318.1 NZ_CP084407:c37179-36892 [Sphingobium sp. CFD-2]
MTMLKTPVHPGEILKHEFLEEMGISAGKLAKHIHVPRTRIERLCEERTSVTPDTAKRLSKALGTTPEFWLNLQTHYDLLM
DQAADIEEIKPLLAA

Download         Length: 288 bp

>AT218525 NZ_CP116026:970597-970860 [Enterococcus casseliflavus]
ATGGAAATGCTACCTATAAAAAAATGGGGCAATAGTAACGGTCTTAGATTGCCAAAGTACATTATGGAGTATCTTGGTAT
TCATACTGATGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGACATAAACGGCTAATCATCGAAGCAGCAAATTTAG
AAAACGAGTTAACGATTGAAGAGTTATTTGAAAACTACACTGCTGAGAGAAATCATGTGGAAATTCAACATTTAGGTGAA
GCAGTAGGAAATGAAAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References