218480

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 913078..913586 Replicon chromosome
Accession NZ_CP084357
Organism Streptomyces sp. WA6-1-16

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LEL86_RS04280 Protein ID WP_150193118.1
Coordinates 913078..913338 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LEL86_RS04285 Protein ID WP_109181470.1
Coordinates 913335..913586 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEL86_RS04260 (LEL86_04260) 908481..909863 + 1383 WP_225679823.1 resuscitation-promoting factor -
LEL86_RS04265 (LEL86_04265) 909860..910735 + 876 WP_109178886.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LEL86_RS04270 (LEL86_04270) 910732..911640 + 909 WP_032767215.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
LEL86_RS04275 (LEL86_04275) 911722..913074 + 1353 WP_225679825.1 acyltransferase -
LEL86_RS04280 (LEL86_04280) 913078..913338 - 261 WP_150193118.1 Txe/YoeB family addiction module toxin Toxin
LEL86_RS04285 (LEL86_04285) 913335..913586 - 252 WP_109181470.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LEL86_RS04290 (LEL86_04290) 913690..914745 - 1056 WP_225679826.1 hypothetical protein -
LEL86_RS04295 (LEL86_04295) 914742..915830 - 1089 WP_225679828.1 hypothetical protein -
LEL86_RS04300 (LEL86_04300) 915948..916322 - 375 WP_225679830.1 hypothetical protein -
LEL86_RS04305 (LEL86_04305) 916470..918287 + 1818 WP_225679832.1 ABC-F family ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10386.74 Da        Isoelectric Point: 9.5040

>T218480 WP_150193118.1 NZ_CP084357:c913338-913078 [Streptomyces sp. WA6-1-16]
VKFVWDQSSWDDYVWWQHQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIHKVVGDEVRIAAC
RYHYGH

Download         Length: 261 bp

>T218480 NZ_CP084357:c913338-913078 [Streptomyces sp. WA6-1-16]
GTGAAGTTCGTGTGGGACCAGTCGTCGTGGGACGACTACGTCTGGTGGCAGCACCAGGATCGCAAGATCCTCAAGAGGAT
CAACACGCTGCTCCAGGACATCGCCCGGAACGGCAACGAAGGAATGGGCAAGCCGGAGCCTCTGAAGCACGGCTTCCAGG
GGTACTGGTCCCGCCGTATCACCGACGAACACCGGCTCATCCACAAAGTGGTCGGCGACGAGGTCCGCATTGCCGCCTGC
CGCTACCACTACGGCCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9258.27 Da        Isoelectric Point: 4.2932

>AT218480 WP_109181470.1 NZ_CP084357:c913586-913335 [Streptomyces sp. WA6-1-16]
MRTMTYTESRANYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLESGGGTVQE
LAE

Download         Length: 252 bp

>AT218480 NZ_CP084357:c913586-913335 [Streptomyces sp. WA6-1-16]
ATGCGCACGATGACCTACACGGAGTCCCGCGCGAATTACGCCGAGACCCTGAGCGCGGTCGTGGACGACCGTGAAGAGGT
CGTGGTCACGCGGGCCGGCCACGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCCCTCAAGGAGACGGCGTACC
AGCTCCGGAGTCCGGAGAACGCCCGTCGACTGCTGGCTTCGATCGACCGCCTGGAGAGCGGCGGCGGCACGGTGCAGGAG
CTTGCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References