Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3563882..3564576 Replicon chromosome
Accession NZ_CP084343
Organism Yersinia pestis strain 20

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag LDH65_RS16145 Protein ID WP_002214787.1
Coordinates 3564280..3564576 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag LDH65_RS16140 Protein ID WP_002209924.1
Coordinates 3563882..3564280 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH65_RS16105 (LDH65_16095) 3559072..3559437 + 366 WP_002209919.1 hypothetical protein -
LDH65_RS16110 (LDH65_16100) 3559450..3559686 + 237 WP_002214792.1 hypothetical protein -
LDH65_RS16115 (LDH65_16105) 3559692..3560024 + 333 WP_002214791.1 hypothetical protein -
LDH65_RS16120 (LDH65_16110) 3560206..3560406 + 201 WP_002209920.1 AlpA family transcriptional regulator -
LDH65_RS16125 (LDH65_16115) 3560420..3560572 - 153 WP_002209921.1 hypothetical protein -
LDH65_RS16130 (LDH65_16120) 3560565..3560891 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDH65_RS16135 (LDH65_16125) 3561191..3563482 + 2292 WP_002209923.1 primase-like DNA-binding domain-containing protein -
LDH65_RS16140 (LDH65_16130) 3563882..3564280 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
LDH65_RS16145 (LDH65_16135) 3564280..3564576 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
LDH65_RS16150 (LDH65_16140) 3564740..3565102 - 363 WP_002209925.1 helix-turn-helix transcriptional regulator -
LDH65_RS16155 (LDH65_16145) 3565165..3565425 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDH65_RS16160 3565797..3565922 + 126 WP_002214784.1 hypothetical protein -
LDH65_RS16165 (LDH65_16150) 3566023..3566208 + 186 WP_002209928.1 hypothetical protein -
LDH65_RS16170 (LDH65_16155) 3566290..3567504 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
LDH65_RS16180 (LDH65_16165) 3567937..3569454 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T218475 WP_002214787.1 NZ_CP084343:c3564576-3564280 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T218475 NZ_CP115992:c1757333-1757232 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCATTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT218475 WP_002209924.1 NZ_CP084343:c3564280-3563882 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT218475 NZ_CP115992:1757108-1757287 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References