Detailed information of TA system TA218460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3168627..3169321
• Replicon: chromosome
• Accession: NZ_CP084339
• Organism: Yersinia pestis strain 94

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: LDH63_RS14400
• Protein ID: WP_002214787.1
• Coordinates: 3169025..3169321 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: LDH63_RS14395
• Protein ID: WP_002209924.1
• Coordinates: 3168627..3169025 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDH63_RS14360 (LDH63_14340)	3163817..3164182	+	366	WP_002209919.1	hypothetical protein	-
LDH63_RS14365 (LDH63_14345)	3164195..3164431	+	237	WP_002214792.1	hypothetical protein	-
LDH63_RS14370 (LDH63_14350)	3164437..3164769	+	333	WP_002214791.1	hypothetical protein	-
LDH63_RS14375 (LDH63_14355)	3164951..3165151	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
LDH63_RS14380 (LDH63_14360)	3165165..3165317	-	153	WP_002209921.1	hypothetical protein	-
LDH63_RS14385 (LDH63_14365)	3165310..3165636	-	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LDH63_RS14390 (LDH63_14370)	3165936..3168227	+	2292	WP_002209923.1	primase-like DNA-binding domain-containing protein	-
LDH63_RS14395 (LDH63_14375)	3168627..3169025	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LDH63_RS14400 (LDH63_14380)	3169025..3169321	-	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LDH63_RS14405 (LDH63_14385)	3169485..3169847	-	363	WP_002209925.1	helix-turn-helix transcriptional regulator	-
LDH63_RS14410 (LDH63_14390)	3169910..3170170	-	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LDH63_RS14415	3170542..3170667	+	126	WP_002214784.1	hypothetical protein	-
LDH63_RS14420 (LDH63_14395)	3170768..3170953	+	186	WP_002209928.1	hypothetical protein	-
LDH63_RS14425 (LDH63_14400)	3171035..3172249	-	1215	WP_002209929.1	tyrosine-type recombinase/integrase	-
LDH63_RS14435 (LDH63_14410)	3172682..3174199	-	1518	WP_002209930.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T218460 WP_002214787.1 NZ_CP084339:c3169321-3169025 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T218460 NZ_CP115960:c2149963-2149640 [Sphingomonas sp. 7/4-4]
ATGAACTTCCTGATCGACGCGCAATTGCCGCCGGCCTTGTGCGGGTGGTTGCGCGAGCGCGGGCATCAGGCGGTGCATGT
GTTCGAGATCGGCATGGTAGCGGCGAGCGATGCGGAGATTGCGGCGCGGGCCGAGGCCGATGGCGCAGTGCTGGTCAGCA
AGGATGAAGACTTCGTGACGCTGCGACTGCCGGATCGGTTTATGTTTGTTTGGTTGCGGTGTGGGAATACGACGAACCGG
GCGCTGGCGGCGTGGCTGGAGGCGCGATGGGAGCAGGTTGAGGCGCTGCTGGAGGCAGGAGAACTGTTTGTAGAAGCAAG
ATAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT218460 WP_002209924.1 NZ_CP084339:c3169025-3168627 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT218460 NZ_CP115960:c2150115-2149960 [Sphingomonas sp. 7/4-4]
GTGCGCGTGACCGACGTGCTGGAAATGCTGGCAGGCGGCGCGAGCCCGGCCGAGATCGCCGGCGACTTTCCGTATCTCAG
CGAGGATGATGTGCGCGCAGTGCTTGCCTATGCGGCGGCACAGGCGGACCATCCGGTGGTGCTCGCCGCCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1