Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3169827..3170521 Replicon chromosome
Accession NZ_CP084336
Organism Yersinia pestis strain R

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag LDH64_RS14405 Protein ID WP_002214787.1
Coordinates 3170225..3170521 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag LDH64_RS14400 Protein ID WP_002209924.1
Coordinates 3169827..3170225 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH64_RS14365 (LDH64_14345) 3165017..3165382 + 366 WP_002209919.1 hypothetical protein -
LDH64_RS14370 (LDH64_14350) 3165395..3165631 + 237 WP_002214792.1 hypothetical protein -
LDH64_RS14375 (LDH64_14355) 3165637..3165969 + 333 WP_002214791.1 hypothetical protein -
LDH64_RS14380 (LDH64_14360) 3166151..3166351 + 201 WP_002209920.1 AlpA family transcriptional regulator -
LDH64_RS14385 (LDH64_14365) 3166365..3166517 - 153 WP_002209921.1 hypothetical protein -
LDH64_RS14390 (LDH64_14370) 3166510..3166836 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDH64_RS14395 (LDH64_14375) 3167136..3169427 + 2292 WP_002209923.1 primase-like DNA-binding domain-containing protein -
LDH64_RS14400 (LDH64_14380) 3169827..3170225 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
LDH64_RS14405 (LDH64_14385) 3170225..3170521 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
LDH64_RS14410 (LDH64_14390) 3170685..3171047 - 363 WP_002209925.1 helix-turn-helix transcriptional regulator -
LDH64_RS14415 (LDH64_14395) 3171110..3171370 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDH64_RS14420 (LDH64_14400) 3171968..3172153 + 186 WP_002209928.1 hypothetical protein -
LDH64_RS14425 (LDH64_14405) 3172235..3173449 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
LDH64_RS14435 (LDH64_14415) 3173882..3175399 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T218446 WP_002214787.1 NZ_CP084336:c3170521-3170225 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T218446 NZ_CP115955:1832564-1833901 [Ralstonia pseudosolanacearum]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCCCGTCGGCATCTGGACAGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGCCTGGTTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCGATCCGCGAGCGCGTGCGG
CGCCGCTTCAGCCTCGCCTCCACGGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCGCCCACCGGCTACGACCGCATCGACAGCGAGCCGCTCACAGACAGCCAGGTCGACGCGCTGC
TGCGCAATCTCACCGCCACACCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAGACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAACTGC
TGACGGCCTGGGGGCTGGAGGTGGCGCACACCGAGATGGCTCGCTTCGGCACCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCCACCGGCACGCCCGC
GCACCGCAAATATGAAAACGACGGCGGCCCCGGCATGCGCACCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTGGCCGCCACCGACGGGCACGCGAAAAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGTTTCCGCATGACGCCGCTGTACGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGACCGACA
TCCACCTGCGCCACTGGCAGGCGCTGGCGGCACAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCTGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGACCAGGTCGAGGCGATCCTGCCGCACGACTTCTCCGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGACCGAGCGCTTTCTCACCGAACTGGCGTCCGTCACCCCATGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT218446 WP_002209924.1 NZ_CP084336:c3170225-3169827 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT218446 NZ_CP115955:1832306-1832560 [Ralstonia pseudosolanacearum]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGTTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAACTGGGCGCGTTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTGCTGCGCATCCTGCACGCGCTCGGCGCGCAGCTGACGCTGCGCACGTCCGCACCCGCCGGCGGCCCCTCCGCCGCG
CCCGCCGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References