Detailed information of TA system TA021842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1044576..1045173
• Replicon: chromosome
• Accession: NC_008767
• Organism: Neisseria meningitidis FAM18

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: NMC_RS05595
• Protein ID: WP_002242826.1
• Coordinates: 1044895..1045173 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NMC_RS05590
• Protein ID: WP_002221020.1
• Coordinates: 1044576..1044887 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMC_RS13825	1040405..1040569	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
NMC_RS05575	1040569..1041180	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
NMC_RS05580	1041177..1041737	+	561	WP_002213590.1	YmfQ family protein	-
NMC_RS05585	1041748..1043721	+	1974	WP_002248050.1	pyocin knob domain-containing protein	-
NMC_RS05590	1044576..1044887	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
NMC_RS05595	1044895..1045173	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NMC_RS05600	1045258..1045863	+	606	WP_002219301.1	hypothetical protein	-
NMC_RS05605	1045842..1046138	+	297	WP_002221017.1	hypothetical protein	-
NMC_RS05610	1046135..1046344	+	210	WP_002222487.1	hypothetical protein	-
NMC_RS05615	1046454..1047597	-	1144	Protein_1058	ABC transporter ATP-binding protein/permease	-
NMC_RS05630	1048039..1048686	-	648	WP_002217218.1	DUF799 domain-containing protein	-
NMC_RS05635	1048683..1049051	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
NMC_RS05640	1049061..1049732	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	877412..1051853	174441
	-	flank	IS/Tn	-	-	1039375..1040340	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T21842 WP_002242826.1 NC_008767:c1045173-1044895 [Neisseria meningitidis FAM18]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T21842 NC_008767:c1045173-1044895 [Neisseria meningitidis FAM18]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT21842 WP_002221020.1 NC_008767:c1044887-1044576 [Neisseria meningitidis FAM18]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT21842 NC_008767:c1044887-1044576 [Neisseria meningitidis FAM18]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6