Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2259842..2260511 Replicon chromosome
Accession NZ_CP084296
Organism Providencia alcalifaciens strain LHC2-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO51_RS10310 Protein ID WP_225574496.1
Coordinates 2259842..2260165 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO51_RS10315 Protein ID WP_225577255.1
Coordinates 2260209..2260511 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO51_RS10295 (LDO51_10295) 2255827..2256516 + 690 WP_036953802.1 phosphate regulon transcriptional regulator PhoB -
LDO51_RS10300 (LDO51_10300) 2256540..2257847 + 1308 WP_225574494.1 phosphate regulon sensor histidine kinase PhoR -
LDO51_RS10305 (LDO51_10305) 2258353..2259681 + 1329 WP_225574495.1 branched-chain amino acid transport system II carrier protein -
LDO51_RS10310 (LDO51_10310) 2259842..2260165 + 324 WP_225574496.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO51_RS10315 (LDO51_10315) 2260209..2260511 + 303 WP_225577255.1 NadS family protein Antitoxin
LDO51_RS10320 (LDO51_10320) 2260560..2262326 - 1767 WP_225574497.1 gamma-glutamyltransferase -
LDO51_RS10325 (LDO51_10325) 2262540..2263142 - 603 WP_036953813.1 peroxiredoxin C -
LDO51_RS10330 (LDO51_10330) 2263350..2263961 - 612 WP_225574498.1 ACP phosphodiesterase -
LDO51_RS10335 (LDO51_10335) 2264155..2265237 + 1083 WP_225574499.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12598.60 Da        Isoelectric Point: 9.8625

>T218405 WP_225574496.1 NZ_CP084296:2259842-2260165 [Providencia alcalifaciens]
MNYLEFMETTVFSKKRKLLMDDTEFQLFQTFLLENYALGDTISHSGGCRKIRWNRTGMGKSSGLRIIYYVRAVSGRIYLL
LIYPKNEQDDLSEQQKLILRTLSKQFS

Download         Length: 324 bp

>T218405 NZ_CP115930:4052856-4053074 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11485.45 Da        Isoelectric Point: 8.7196

>AT218405 WP_225577255.1 NZ_CP084296:2260209-2260511 [Providencia alcalifaciens]
MEKTLFNDLVSSMEEMIAIEKGEKIPSSENIHRHELPDVKAIRKQAGMKQQEFAEAIGLSVDLVRSWEQKRRTPSGIALK
MLFLLEKQPGIINFLRTIHI

Download         Length: 303 bp

>AT218405 NZ_CP115930:4052455-4052829 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References