Detailed information of TA system TA021839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 20814..21520
• Replicon: plasmid pPNAP04
• Accession: NC_008760
• Organism: Polaromonas naphthalenivorans CJ2

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A1VWM5
• Locus tag: PNAP_RS23760
• Protein ID: WP_011798424.1
• Coordinates: 20814..21116 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A1VWM6
• Locus tag: PNAP_RS23765
• Protein ID: WP_011798425.1
• Coordinates: 21119..21520 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PNAP_RS23735	16736..17200	-	465	WP_041377794.1	hypothetical protein	-
PNAP_RS23740	17527..17736	+	210	WP_041377762.1	transposase	-
PNAP_RS23745	17675..17953	+	279	WP_157040544.1	hypothetical protein	-
PNAP_RS23750	18006..19049	-	1044	WP_076611837.1	IS701-like element ISPna6 family transposase	-
PNAP_RS27430	19363..19512	-	150	WP_157040545.1	hypothetical protein	-
PNAP_RS23755	19862..20719	+	858	WP_011798423.1	carboxylating nicotinate-nucleotide diphosphorylase	-
PNAP_RS23760	20814..21116	+	303	WP_011798424.1	type II toxin-antitoxin system MqsR family toxin	Toxin
PNAP_RS23765	21119..21520	+	402	WP_011798425.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
PNAP_RS23770	22595..22801	+	207	WP_157040546.1	hypothetical protein	-
PNAP_RS23775	22839..25060	+	2222	Protein_26	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..143747	143747
	-	flank	IS/Tn	-	-	18006..18986	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10993.70 Da
• Isoelectric Point: 7.2418

>T21839 WP_011798424.1 NC_008760:20814-21116 [Polaromonas naphthalenivorans CJ2]
MEKGTPHCKLSVVKALIEADRVKATASAFNGARDLGINDLAGMCAVVMSLTSTDFYKSMTTHADHRIWQDVYRAKTANSA
DVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T21839 NC_008760:20814-21116 [Polaromonas naphthalenivorans CJ2]
ATGGAAAAAGGCACCCCTCACTGCAAGTTGTCAGTCGTGAAAGCCTTGATCGAAGCCGATAGGGTCAAGGCCACGGCCAG
CGCCTTCAATGGTGCGCGTGACTTGGGTATCAATGACCTGGCTGGAATGTGTGCTGTCGTCATGTCGCTCACGTCCACTG
ACTTCTACAAGAGCATGACGACCCACGCCGATCACCGGATTTGGCAGGATGTGTACCGCGCCAAGACAGCCAACAGTGCC
GATGTGTACTTGAAGCTGACCGTCATTGATGATGTTTTGATCGTTTCTTTCAAGGAGCTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14916.02 Da
• Isoelectric Point: 7.1653

>AT21839 WP_011798425.1 NC_008760:21119-21520 [Polaromonas naphthalenivorans CJ2]
MKCPCCGAAELIHDTRDMPYTYKGETATIPAVTGDFCPACGEVILNREHGDRYSELLGQFQRQVNAAYIDPDYIARVRKK
LDLDQRQAAEIFGGGVNAFSRYENGKTRPSLALVKLLKVLERHPDLLNEVRTT

Nucleotide

• Length: 402 bp

>AT21839 NC_008760:21119-21520 [Polaromonas naphthalenivorans CJ2]
ATGAAATGCCCATGCTGTGGAGCGGCTGAACTGATCCACGACACCCGCGATATGCCCTACACCTACAAGGGCGAAACCGC
CACCATTCCAGCGGTGACAGGCGACTTCTGCCCGGCCTGCGGCGAGGTCATTCTGAACCGTGAGCACGGCGACCGATACA
GCGAGTTGCTGGGGCAGTTCCAGCGCCAGGTGAACGCGGCCTATATCGATCCAGACTACATCGCCAGGGTGCGCAAGAAG
CTCGATCTGGATCAACGCCAAGCCGCCGAAATCTTCGGTGGCGGGGTCAATGCCTTCTCACGCTACGAAAACGGCAAGAC
CAGGCCGTCCTTGGCCTTGGTGAAGCTGCTCAAGGTGCTTGAGCGTCATCCCGATCTACTCAACGAGGTCAGAACCACCT
GA

Structures

Toxin

• AlphaFold DB: A1VWM5

Antitoxin

• AlphaFold DB: A1VWM6