Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2893980..2894655 Replicon chromosome
Accession NZ_CP084265
Organism Caballeronia sp. Lep1P3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDZ27_RS13565 Protein ID WP_244814579.1
Coordinates 2893980..2894327 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDZ27_RS13570 Protein ID WP_244814580.1
Coordinates 2894320..2894655 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ27_RS13545 2889466..2890425 - 960 WP_244814575.1 MlaD family protein -
LDZ27_RS13550 2890468..2891343 - 876 WP_244814576.1 ATP-binding cassette domain-containing protein -
LDZ27_RS13555 2891349..2892476 - 1128 WP_244814577.1 ABC transporter permease -
LDZ27_RS13560 2892716..2893813 - 1098 WP_244814578.1 IS5 family transposase -
LDZ27_RS13565 2893980..2894327 + 348 WP_244814579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDZ27_RS13570 2894320..2894655 + 336 WP_244814580.1 helix-turn-helix transcriptional regulator Antitoxin
LDZ27_RS13575 2894714..2895625 + 912 WP_244814581.1 biotin--[acetyl-CoA-carboxylase] ligase -
LDZ27_RS13580 2895622..2896452 + 831 WP_244814582.1 type III pantothenate kinase -
LDZ27_RS13585 2896470..2896712 + 243 WP_244814583.1 hypothetical protein -
LDZ27_RS13590 2896722..2897204 - 483 WP_244814584.1 D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase -
LDZ27_RS13595 2897348..2898223 - 876 WP_244814585.1 ferritin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2892716..2893813 1097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(24-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-106)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13226.47 Da        Isoelectric Point: 11.1304

>T218375 WP_244814579.1 NZ_CP084265:2893980-2894327 [Caballeronia sp. Lep1P3]
MLTSDTGPWTIAYYSARVKDEVWQLPPGILASYFRLTRPLREHGPGLPLPHARPMGDKLFELRPAGHDGIGRVFYCTLEG
RRIVILHSFAKKTQRTPLKELHLARKRLKEVRRNG

Download         Length: 348 bp

>T218375 NZ_CP115887:c2546594-2546328 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12157.80 Da        Isoelectric Point: 6.4661

>AT218375 WP_244814580.1 NZ_CP084265:2894320-2894655 [Caballeronia sp. Lep1P3]
MAKTRWQQQMEARYDPVPHSDEEVAQMFAADPALKAAYDALEDEYAALDALLRARKEAGLTQAQVAERMGTTASAVARLE
GSLVSEKHSPTLATLRKYATACGKTLRISFV

Download         Length: 336 bp

>AT218375 NZ_CP115887:c2546851-2546594 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References