Detailed information of TA system TA021835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1754529..1755120
• Replicon: chromosome
• Accession: NC_008751
• Organism: Desulfovibrio vulgaris DP4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DVUL_RS07500
• Protein ID: WP_043629397.1
• Coordinates: 1754529..1754807 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DVUL_RS07505
• Protein ID: WP_011792270.1
• Coordinates: 1754818..1755120 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVUL_RS07475	1749730..1750665	-	936	WP_011792264.1	hypothetical protein	-
DVUL_RS07480	1750668..1751204	-	537	WP_011792265.1	hypothetical protein	-
DVUL_RS17415	1751770..1752618	-	849	Protein_1441	phage tail protein	-
DVUL_RS07490	1752615..1753226	-	612	WP_011792267.1	hypothetical protein	-
DVUL_RS07495	1753223..1754434	-	1212	WP_011792268.1	baseplate J/gp47 family protein	-
DVUL_RS07500	1754529..1754807	+	279	WP_043629397.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DVUL_RS07505	1754818..1755120	+	303	WP_011792270.1	HigA family addiction module antidote protein	Antitoxin
DVUL_RS07510	1755141..1755467	-	327	WP_011792271.1	DUF2590 family protein	-
DVUL_RS07515	1755471..1757267	-	1797	WP_011792272.1	phage tail tape measure protein	-
DVUL_RS07520	1757473..1757733	-	261	WP_011792274.1	putative phage tail assembly chaperone	-
DVUL_RS07525	1757743..1758057	-	315	WP_011792275.1	hypothetical protein	-
DVUL_RS07530	1758054..1758320	-	267	WP_043629399.1	Rz1-like lysis system protein LysC	-
DVUL_RS07535	1758253..1758603	-	351	WP_011792276.1	hypothetical protein	-
DVUL_RS07540	1758600..1759028	-	429	WP_011792277.1	hypothetical protein	-
DVUL_RS07545	1759025..1759231	-	207	WP_011792278.1	TraR/DksA C4-type zinc finger protein	-
DVUL_RS07550	1759240..1759728	-	489	WP_011792279.1	DUF2597 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1743434..1789655	46221

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10583.98 Da
• Isoelectric Point: 8.5731

>T21835 WP_043629397.1 NC_008751:1754529-1754807 [Desulfovibrio vulgaris DP4]
MIRSFAHKGLEDLFYDGTTKGVQQKHVRKLLDVLDLLDNAREVKDMGFPGSGLHQLKGNLNGHWAVKISGNWRMTFRFEN
GDAHVVNYQDYH

Nucleotide

• Length: 279 bp

>T21835 NC_008751:1754529-1754807 [Desulfovibrio vulgaris DP4]
ATGATTCGCAGCTTTGCGCACAAGGGCCTTGAAGACCTGTTCTACGATGGTACAACCAAAGGCGTACAACAGAAGCATGT
ACGCAAGCTGCTTGACGTTCTCGACCTTCTCGACAACGCACGAGAGGTCAAAGACATGGGCTTTCCCGGTTCGGGGCTGC
ACCAGCTCAAGGGAAATCTCAACGGCCACTGGGCTGTGAAGATCTCCGGCAACTGGCGAATGACCTTCCGATTCGAGAAC
GGAGACGCCCATGTCGTGAACTATCAGGACTATCACTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11244.09 Da
• Isoelectric Point: 12.2681

>AT21835 WP_011792270.1 NC_008751:1754818-1755120 [Desulfovibrio vulgaris DP4]
MRTRTRKPTHPGGILHRMHMEPLGLTITALAQQLGISRKALSAIVNERAAITPDIALRLSRALNTTPELWLNMQQAFTLW
ETAHTRTEWRAVQPVRAANA

Nucleotide

• Length: 303 bp

>AT21835 NC_008751:1754818-1755120 [Desulfovibrio vulgaris DP4]
ATGCGCACCCGCACCAGAAAGCCCACGCACCCCGGCGGCATCCTGCACAGGATGCACATGGAGCCGCTCGGCCTGACGAT
CACGGCACTTGCGCAGCAGCTTGGCATTTCGCGCAAGGCCCTTTCGGCCATCGTGAATGAGCGCGCGGCCATCACGCCCG
ACATCGCCTTGCGACTCTCTCGCGCCCTCAACACCACCCCGGAACTCTGGCTGAACATGCAGCAGGCGTTCACGCTGTGG
GAGACCGCCCACACGCGAACCGAATGGCGTGCCGTGCAGCCCGTTAGAGCCGCCAACGCATAG