Detailed information of TA system TA218321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4405924..4406526
• Replicon: chromosome
• Accession: NZ_CP084216
• Organism: Salmonella sp. JXY0409-18

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: LDB27_RS21365
• Protein ID: WP_001159631.1
• Coordinates: 4406215..4406526 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LDB27_RS21360
• Protein ID: WP_000362050.1
• Coordinates: 4405924..4406214 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDB27_RS21345 (4403417)	4403417..4404319	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
LDB27_RS21350 (4404316)	4404316..4404951	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LDB27_RS21355 (4404948)	4404948..4405877	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LDB27_RS21360 (4405924)	4405924..4406214	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LDB27_RS21365 (4406215)	4406215..4406526	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LDB27_RS21370 (4406744)	4406744..4407673	+	930	WP_001127691.1	alpha/beta hydrolase	-
LDB27_RS21375 (4407759)	4407759..4408070	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
LDB27_RS21380 (4408067)	4408067..4408513	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LDB27_RS21385 (4408528)	4408528..4409469	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LDB27_RS21390 (4409514)	4409514..4409951	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
LDB27_RS21395 (4409948)	4409948..4410820	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LDB27_RS21400 (4410814)	4410814..4411413	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T218321 WP_001159631.1 NZ_CP084216:c4406526-4406215 [Salmonella sp. JXY0409-18]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T218321 NZ_CP115831:c4892729-4891812 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT218321 WP_000362050.1 NZ_CP084216:c4406214-4405924 [Salmonella sp. JXY0409-18]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT218321 NZ_CP115831:c4893493-4892735 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTTGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATTCCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3