Detailed information of TA system TA218293

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3902990..3903402
• Replicon: chromosome
• Accession: NZ_CP084209
• Organism: Escherichia coli strain EC2648-R2

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: LDB16_RS19035
• Protein ID: WP_000132601.1
• Coordinates: 3903061..3903402 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3902990..3903066 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDB16_RS19025 (3899853)	3899853..3901442	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
LDB16_RS19030 (3901439)	3901439..3902833	+	1395	WP_072647344.1	type I restriction-modification system specificity subunit	-
- (3902990)	3902990..3903066	-	77	NuclAT_14	-	Antitoxin
- (3902990)	3902990..3903066	-	77	NuclAT_14	-	Antitoxin
- (3902990)	3902990..3903066	-	77	NuclAT_14	-	Antitoxin
- (3902990)	3902990..3903066	-	77	NuclAT_14	-	Antitoxin
- (3902990)	3902990..3903066	-	77	NuclAT_15	-	Antitoxin
- (3902990)	3902990..3903066	-	77	NuclAT_15	-	Antitoxin
- (3902990)	3902990..3903066	-	77	NuclAT_15	-	Antitoxin
- (3902990)	3902990..3903066	-	77	NuclAT_15	-	Antitoxin
LDB16_RS19035 (3903061)	3903061..3903402	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
LDB16_RS19040 (3903564)	3903564..3904943	+	1380	WP_072647343.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
LDB16_RS19045 (3904943)	3904943..3905989	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T218293 WP_000132601.1 NZ_CP084209:3903061-3903402 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T218293 NZ_CP115780:c193966-193397 [Paracoccus aerodenitrificans]
ATGAGCCAGTACACGGTGCTGTTCGACGCGAATGTTCTCTACCCCGCGCCAATGCGGGACGCGCTGATGCAATTGGCTGT
CACAGATCTTTTCAAGGCGAAGTGGACGGCTGACATCCATCGGGAATGGATCGACGCCCTTCTACGCAATGAACCTCATC
GAGAACGGGCGGCGCTCGAGCGGACCCGCGACCTGATGGATAGGGCAACACGCGACTGCCTAGTCACCGGCTATGAGGCC
TTGGTGCCGGCCCTCATATTGCCGGATCCCGACGACCGGCACGTTCTGGCGGCCGCTATCGTCGGGCGCTGTGACGCCAT
CGTCACTCAGAACATGAAGGACTTCCCACCAGAGGCACTTGTACCATTCGGCATCGAAACTCAGCACCCCGACGACTTTT
TCCGGAACCAGCTTTCTCTCGCGCCCGGTCTGGTTTGTTCAGCGCTGCGCAAAGTTCGCGCGCGCCTCAAAAACCCGCCC
AAGAGCGTTGACGAGTATCTGTCGATCCTGACACAGCAAGGGCTGGTCGCCACTGTAGCGGATCTGGAACAGTTCGCCGA
TCTGCTTTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT218293 NZ_CP084209:c3903066-3902990 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin