Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 3588550..3589244 | Replicon | chromosome |
| Accession | NZ_CP084209 | ||
| Organism | Escherichia coli strain EC2648-R2 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | Q47157 |
| Locus tag | LDB16_RS17555 | Protein ID | WP_001263489.1 |
| Coordinates | 3588550..3588948 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1QAE3 |
| Locus tag | LDB16_RS17560 | Protein ID | WP_000554758.1 |
| Coordinates | 3588951..3589244 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (3584138) | 3584138..3584218 | - | 81 | NuclAT_12 | - | - |
| - (3584138) | 3584138..3584218 | - | 81 | NuclAT_12 | - | - |
| - (3584138) | 3584138..3584218 | - | 81 | NuclAT_12 | - | - |
| - (3584138) | 3584138..3584218 | - | 81 | NuclAT_12 | - | - |
| LDB16_RS17530 (3584814) | 3584814..3585272 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| LDB16_RS17535 (3585533) | 3585533..3586990 | + | 1458 | WP_001292994.1 | cytosol nonspecific dipeptidase | - |
| LDB16_RS17540 (3587047) | 3587047..3587568 | - | 522 | Protein_3448 | peptide chain release factor H | - |
| LDB16_RS17545 (3587564) | 3587564..3587770 | - | 207 | Protein_3449 | RtcB family protein | - |
| LDB16_RS17550 (3588088) | 3588088..3588540 | - | 453 | WP_001059892.1 | GNAT family N-acetyltransferase | - |
| LDB16_RS17555 (3588550) | 3588550..3588948 | - | 399 | WP_001263489.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| LDB16_RS17560 (3588951) | 3588951..3589244 | - | 294 | WP_000554758.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| LDB16_RS17565 (3589296) | 3589296..3590351 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
| LDB16_RS17570 (3590422) | 3590422..3591207 | - | 786 | WP_000207552.1 | putative lateral flagellar export/assembly protein LafU | - |
| LDB16_RS17575 (3591179) | 3591179..3592891 | + | 1713 | Protein_3455 | flagellar biosynthesis protein FlhA | - |
| LDB16_RS17580 (3593115) | 3593115..3593612 | - | 498 | WP_000006255.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15487.84 Da Isoelectric Point: 7.4215
>T218291 WP_001263489.1 NZ_CP084209:c3588948-3588550 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T218291 NZ_CP115778:7283-7858 [Paracoccus albus]
ATGAGCCGATACGCTGATCGGTTCACGGCTCTCCTCGATGCCTGCGTCCTGGGCGGAGCGCTTCGCAGAAACATGCTCCT
GAGCCTGGCCGAGGCCGGCTTGTTCCGGCCTCGGTGGAGCAGTCGCATTCTTGACGAGACCCAGAAAGCGATCACCCAGA
TCACCAAGGGCGAAACCGATGGTTCCCGGCAGAGGGCGGCAATCGAGGCGGCGTTCCCTGAAGCGCTGGTGACGGGTTAT
GAGATCTTCGAAGAAAAGCTCGCGTTGCCCGACCCCAACGACAACCACGTGCTGGCAGCGGCCATCGCGACATCTGCTTC
AGTCATCGTGACGGACAATCTCGCCGACTTTCCTTCCGCCGTTCTGGACCCGCACGCCATCCAGGCGATTTCCGCCGACG
ACTTCATCGCCGATACAATCGAGCTGGATCCCTCGGAGGCCATTCTGGCCCTGCGTCGCATGCGGGAGCGCTTCAAAAAT
CCAGCGCTCGATGTTGCGGCTTTGATTCACAAGTCAGAAGCGCAAGGCCTATTGCAGGTTGCAACCTTCATGGACGAGTA
TCAGTCGTTCCTGTAG
ATGAGCCGATACGCTGATCGGTTCACGGCTCTCCTCGATGCCTGCGTCCTGGGCGGAGCGCTTCGCAGAAACATGCTCCT
GAGCCTGGCCGAGGCCGGCTTGTTCCGGCCTCGGTGGAGCAGTCGCATTCTTGACGAGACCCAGAAAGCGATCACCCAGA
TCACCAAGGGCGAAACCGATGGTTCCCGGCAGAGGGCGGCAATCGAGGCGGCGTTCCCTGAAGCGCTGGTGACGGGTTAT
GAGATCTTCGAAGAAAAGCTCGCGTTGCCCGACCCCAACGACAACCACGTGCTGGCAGCGGCCATCGCGACATCTGCTTC
AGTCATCGTGACGGACAATCTCGCCGACTTTCCTTCCGCCGTTCTGGACCCGCACGCCATCCAGGCGATTTCCGCCGACG
ACTTCATCGCCGATACAATCGAGCTGGATCCCTCGGAGGCCATTCTGGCCCTGCGTCGCATGCGGGAGCGCTTCAAAAAT
CCAGCGCTCGATGTTGCGGCTTTGATTCACAAGTCAGAAGCGCAAGGCCTATTGCAGGTTGCAACCTTCATGGACGAGTA
TCAGTCGTTCCTGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.76 Da Isoelectric Point: 5.2170
>AT218291 WP_000554758.1 NZ_CP084209:c3589244-3588951 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT218291 NZ_CP115778:6822-7286 [Paracoccus albus]
ATGAACGCCCTCAGAAAAGAGGCGTTCTTTGATCGTTTGCCCGACGAGGTCGAGATCAAGAACGCCGAACAACTCAGAAC
GATTGTCGCCTCCCAGATCAAGGAAGGCGAACCGACAAAGCTGTCGCTCGCCCTAGAAGGCGGCGAAGTTCGCACCGTGA
CACTTGCGCCCGCCCTGACGGCTTCGCTGCTCGAGGTGCTGCGACTTGTGTCGAGCGGTCGCGGGTTCCGGATGATTCCC
GTCGAGTCAGAGCTGACCACGCAGCAGGCGGCGGACCTTCTCAATGTGTCCCGCCCGTTCCTGGTGAAGCTTCTCGAGGA
AGGCGAGATTCCGTTTGCGAAGACCGGCCGTCATCGCCGTGTTCGTGCAGACGATCTTTTTGCCTACAAGGAGAAGCGTG
ACGCGTCTCGCTCTGATGCTTTGAGTGGCCTTGCTGCAATGGATGCGGAAGAAGGTCTTGTATGA
ATGAACGCCCTCAGAAAAGAGGCGTTCTTTGATCGTTTGCCCGACGAGGTCGAGATCAAGAACGCCGAACAACTCAGAAC
GATTGTCGCCTCCCAGATCAAGGAAGGCGAACCGACAAAGCTGTCGCTCGCCCTAGAAGGCGGCGAAGTTCGCACCGTGA
CACTTGCGCCCGCCCTGACGGCTTCGCTGCTCGAGGTGCTGCGACTTGTGTCGAGCGGTCGCGGGTTCCGGATGATTCCC
GTCGAGTCAGAGCTGACCACGCAGCAGGCGGCGGACCTTCTCAATGTGTCCCGCCCGTTCCTGGTGAAGCTTCTCGAGGA
AGGCGAGATTCCGTTTGCGAAGACCGGCCGTCATCGCCGTGTTCGTGCAGACGATCTTTTTGCCTACAAGGAGAAGCGTG
ACGCGTCTCGCTCTGATGCTTTGAGTGGCCTTGCTGCAATGGATGCGGAAGAAGGTCTTGTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A090J8B1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1QAE3 |