Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 717224..717917 Replicon chromosome
Accession NZ_CP084209
Organism Escherichia coli strain EC2648-R2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LDB16_RS03495 Protein ID WP_000415584.1
Coordinates 717224..717520 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LDB16_RS03500 Protein ID WP_000650107.1
Coordinates 717522..717917 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB16_RS03460 (712312) 712312..712626 - 315 WP_000958598.1 putative quinol monooxygenase -
LDB16_RS03465 (712657) 712657..713238 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LDB16_RS03470 (713557) 713557..713889 + 333 WP_000917684.1 DUF2645 family protein -
LDB16_RS03475 (713935) 713935..715284 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LDB16_RS03480 (715281) 715281..715940 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
LDB16_RS03485 (716092) 716092..716484 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LDB16_RS03490 (716537) 716537..717019 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LDB16_RS03495 (717224) 717224..717520 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LDB16_RS03500 (717522) 717522..717917 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LDB16_RS03505 (718050) 718050..719657 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LDB16_RS03510 (719795) 719795..722053 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T218271 WP_000415584.1 NZ_CP084209:717224-717520 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T218271 NZ_CP115714:c4692106-4691822 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT218271 WP_000650107.1 NZ_CP084209:717522-717917 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT218271 NZ_CP115714:c4692338-4692096 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References