Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2599664..2600166 | Replicon | chromosome |
| Accession | NZ_CP084207 | ||
| Organism | Escherichia coli strain EC2648-R1-1 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | LDB15_RS12320 | Protein ID | WP_000767829.1 |
| Coordinates | 2599912..2600166 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | LDB15_RS12315 | Protein ID | WP_001259255.1 |
| Coordinates | 2599664..2599915 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDB15_RS12290 (2594842) | 2594842..2595909 | - | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| LDB15_RS12295 (2595909) | 2595909..2596979 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| LDB15_RS12300 (2596976) | 2596976..2598280 | - | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| LDB15_RS12305 (2598286) | 2598286..2599185 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| LDB15_RS12310 (2599331) | 2599331..2599381 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| LDB15_RS12315 (2599664) | 2599664..2599915 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| LDB15_RS12320 (2599912) | 2599912..2600166 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| LDB15_RS12325 (2600249) | 2600249..2601073 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| LDB15_RS12330 (2601119) | 2601119..2602048 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| LDB15_RS12335 (2602263) | 2602263..2602325 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| LDB15_RS12340 (2602315) | 2602315..2603673 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| LDB15_RS12345 (2603852) | 2603852..2604910 | + | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| LDB15_RS12350 (2604924) | 2604924..2605151 | + | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T218245 WP_000767829.1 NZ_CP084207:2599912-2600166 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T218245 NZ_CP115712:301029-301427 [Kosakonia pseudosacchari]
ATGGATTCTATGGGCATTTACCTGACAAGGGAATTTGATCAGGAACGCAGACGAGTGCGTGTTAGCGATAAAATATTACG
CAAAGCGGCCCTGGCGATTGTTGCTGGTTTACCGGGCGACAAATTAGGTAAATATACCTACAAAAAACGTATCGCATTAC
CCGCAGTCAGTGCGCGGGATGGCGCTCGCGCTATAGTCTTTTTTCATGCAGGAGAAAATCTCTTTTTCTTCGACATGTAT
GTAAAAAGCGAACTCTCTAAAAAGAGAGGTAAAGAGCTTGAAGATGATGAAATAGATGCTTACTGCGCCATTGCGAAAGA
TTTTATCGCAATGCCTGCTGATACACTGAAACGGCTATTAAGCAGTAAAGATTTAATCGAGGTGAACTGTTATGAGTGA
ATGGATTCTATGGGCATTTACCTGACAAGGGAATTTGATCAGGAACGCAGACGAGTGCGTGTTAGCGATAAAATATTACG
CAAAGCGGCCCTGGCGATTGTTGCTGGTTTACCGGGCGACAAATTAGGTAAATATACCTACAAAAAACGTATCGCATTAC
CCGCAGTCAGTGCGCGGGATGGCGCTCGCGCTATAGTCTTTTTTCATGCAGGAGAAAATCTCTTTTTCTTCGACATGTAT
GTAAAAAGCGAACTCTCTAAAAAGAGAGGTAAAGAGCTTGAAGATGATGAAATAGATGCTTACTGCGCCATTGCGAAAGA
TTTTATCGCAATGCCTGCTGATACACTGAAACGGCTATTAAGCAGTAAAGATTTAATCGAGGTGAACTGTTATGAGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT218245 WP_001259255.1 NZ_CP084207:2599664-2599915 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT218245 NZ_CP115712:301420-301737 [Kosakonia pseudosacchari]
ATGAGTGACCATCTGAAACGTATTCAGAGTATGGCAAAACGCTACAATGCGCTGGGTGTGGTGCAGGATGAAACGGTTGC
GGCGATTGATGAAGCTATCGATGCGCGTAATATTCCACAGGTTCGTCCAATGACCGGTGTGCAAATCAAACAGGTCCGTG
CTCGCTGGAAAATGTCACAAGCGGCGCTGGCTCGCACTGTCGGGATGTCAGTTGAAAGTGTGTCGAAGTGGGAACGTAAC
GAAAGCAAACCTAATAATGCCGCTTTACGTATCCTCAATACGATTGAAGATAAAGGGCCGGCTGTGTTTCTTGGCTAA
ATGAGTGACCATCTGAAACGTATTCAGAGTATGGCAAAACGCTACAATGCGCTGGGTGTGGTGCAGGATGAAACGGTTGC
GGCGATTGATGAAGCTATCGATGCGCGTAATATTCCACAGGTTCGTCCAATGACCGGTGTGCAAATCAAACAGGTCCGTG
CTCGCTGGAAAATGTCACAAGCGGCGCTGGCTCGCACTGTCGGGATGTCAGTTGAAAGTGTGTCGAAGTGGGAACGTAAC
GAAAGCAAACCTAATAATGCCGCTTTACGTATCCTCAATACGATTGAAGATAAAGGGCCGGCTGTGTTTCTTGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|