Detailed information of TA system TA218236

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 992670..992892
• Replicon: chromosome
• Accession: NZ_CP084207
• Organism: Escherichia coli strain EC2648-R1-1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: LDB15_RS04700
• Protein ID: WP_000141634.1
• Coordinates: 992785..992892 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	992670..992736 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDB15_RS04680	988111..989013	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
LDB15_RS04685	989024..990007	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
LDB15_RS04690	990004..991008	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
LDB15_RS04695	991038..992309	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	992670..992736	-	67	-	-	Antitoxin
LDB15_RS04700	992785..992892	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
LDB15_RS04705	992979..994658	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
LDB15_RS04710	994655..994846	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LDB15_RS04715	994843..996414	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LDB15_RS04720	996687..996875	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
LDB15_RS04725	996911..997639	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T218236 WP_000141634.1 NZ_CP084207:992785-992892 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T218236 NZ_CP115707:c4622681-4622148 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT218236 NZ_CP084207:c992736-992670 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin