Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 194973..195694 Replicon plasmid pCB1A
Accession NZ_CP084198
Organism Pantoea agglomerans strain CB1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO72_RS20290 Protein ID WP_143789442.1
Coordinates 194973..195284 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO72_RS20295 Protein ID WP_031590724.1
Coordinates 195281..195694 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO72_RS20280 (LDO72_20305) 191676..192968 - 1293 WP_039389956.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -
LDO72_RS20285 (LDO72_20310) 192979..194532 - 1554 WP_275103279.1 aspartate aminotransferase family protein -
LDO72_RS20290 (LDO72_20315) 194973..195284 + 312 WP_143789442.1 type II toxin-antitoxin system HigB family toxin Toxin
LDO72_RS20295 (LDO72_20320) 195281..195694 + 414 WP_031590724.1 helix-turn-helix domain-containing protein Antitoxin
LDO72_RS20300 (LDO72_20325) 195810..197183 - 1374 WP_031590723.1 PTS ascorbate transporter subunit IIC -
LDO72_RS20305 (LDO72_20330) 197223..197495 - 273 WP_003855084.1 PTS sugar transporter subunit IIB -
LDO72_RS20310 (LDO72_20335) 197544..197993 - 450 WP_275103280.1 PTS sugar transporter subunit IIA -
LDO72_RS20315 (LDO72_20340) 198570..199304 + 735 WP_275103281.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..569555 569555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12181.08 Da        Isoelectric Point: 9.9086

>T218191 WP_143789442.1 NZ_CP084198:194973-195284 [Pantoea agglomerans]
MHIISRGPFREAAIIYPNHASALDAAYLVLRDENFATSDALKIRFQSLDRMKYREKWWVIDVGGNSLRIMFYADFDRGKI
FIKHIVTHAEYDKLVKKFRESKE

Download         Length: 312 bp

>T218191 NZ_CP115672:3568313-3568612 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15420.44 Da        Isoelectric Point: 4.9795

>AT218191 WP_031590724.1 NZ_CP084198:195281-195694 [Pantoea agglomerans]
MITEAIQATNDLVRIVPFLGGSTDKRDYEQALELVEYLVEHQPDSPLVEILSDKVARYENSAPEFAAFNARTDAMPRGVA
LLRVIMDQHGLTQSSFADEIGQRSYVSRILRGDRPLTDKHKARLAARFNLPFEAFAE

Download         Length: 414 bp

>AT218191 NZ_CP115672:3568623-3568988 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References