Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3851250..3851895 Replicon chromosome
Accession NZ_CP084197
Organism Pantoea agglomerans strain CB1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LDO72_RS18070 Protein ID WP_143789799.1
Coordinates 3851542..3851895 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LDO72_RS18065 Protein ID WP_022625233.1
Coordinates 3851250..3851549 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO72_RS18050 (LDO72_18065) 3847163..3848947 - 1785 WP_010252112.1 GMC family oxidoreductase -
LDO72_RS18055 (LDO72_18070) 3848950..3849684 - 735 WP_033787533.1 gluconate 2-dehydrogenase subunit 3 family protein -
LDO72_RS18060 (LDO72_18075) 3849961..3851202 + 1242 WP_275102581.1 peptide antibiotic transporter SbmA -
LDO72_RS18065 (LDO72_18080) 3851250..3851549 - 300 WP_022625233.1 helix-turn-helix transcriptional regulator Antitoxin
LDO72_RS18070 (LDO72_18085) 3851542..3851895 - 354 WP_143789799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO72_RS18075 (LDO72_18090) 3852105..3853157 - 1053 WP_275102582.1 YncE family protein -
LDO72_RS18080 (LDO72_18095) 3853360..3853569 - 210 WP_009092571.1 DUF1471 domain-containing protein -
LDO72_RS18085 (LDO72_18100) 3853782..3854969 - 1188 WP_275102583.1 MFS transporter -
LDO72_RS18090 (LDO72_18105) 3855075..3856040 + 966 WP_064704971.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13411.27 Da        Isoelectric Point: 6.4741

>T218188 WP_143789799.1 NZ_CP084197:c3851895-3851542 [Pantoea agglomerans]
MWDVDTTKRFDEWFKAQTEELKEDMLAAIVILSEYGPHLARPFADTVDGSDFSNMKELRVQHQGKPIRAFFAFDPSRRGI
VLCAGDKTGVKEKKFYKDMIKLADAEFRKYLNGGDNG

Download         Length: 354 bp

>T218188 NZ_CP115672:c1102883-1102665 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11131.98 Da        Isoelectric Point: 9.8103

>AT218188 WP_022625233.1 NZ_CP084197:c3851549-3851250 [Pantoea agglomerans]
MANLKELMANQSPESRERIAKKVDAMRQVIALHMLREELNLSQTEMAHAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVKLPTGKRIAFDL

Download         Length: 300 bp

>AT218188 NZ_CP115672:c1103285-1102911 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References