Detailed information of TA system TA218177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4697817..4698419
• Replicon: chromosome
• Accession: NZ_CP084194
• Organism: Salmonella sp. A39

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: LDO68_RS22915
• Protein ID: WP_001159630.1
• Coordinates: 4698108..4698419 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LDO68_RS22910
• Protein ID: WP_000362050.1
• Coordinates: 4697817..4698107 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO68_RS22895 (4695310)	4695310..4696212	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
LDO68_RS22900 (4696209)	4696209..4696844	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LDO68_RS22905 (4696841)	4696841..4697770	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LDO68_RS22910 (4697817)	4697817..4698107	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LDO68_RS22915 (4698108)	4698108..4698419	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LDO68_RS22920 (4698637)	4698637..4699566	+	930	WP_001127703.1	alpha/beta hydrolase	-
LDO68_RS22925 (4699652)	4699652..4699963	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
LDO68_RS22930 (4699960)	4699960..4700406	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
LDO68_RS22935 (4700421)	4700421..4701362	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LDO68_RS22940 (4701407)	4701407..4701844	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
LDO68_RS22945 (4701841)	4701841..4702713	-	873	WP_000921427.1	virulence factor BrkB family protein	-
LDO68_RS22950 (4702707)	4702707..4703306	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T218177 WP_001159630.1 NZ_CP084194:c4698419-4698108 [Salmonella sp. A39]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T218177 NZ_CP115669:784710-784961 [Pseudomonas sp. PSE14]
ATGTCTCAGCATGAGAAGCTGCTGGCAAAGCTATTGAACAAGCAGTCCGTGCTTACCTGGCAGGAACTGGTGGTGTTGCT
CCACGGGCTTGGCTATCGGAAGCTCGAGGGCGATGGCAGTCGGGTCAAATTCGATAATGGCGACCCGCGAGCAATGATCA
ACCTGCACAAACCCCATCCCGGCAATGAATTGAAGGCCTATGCCAGGCGCCAGGTGATCGAACATCTGAAAAGCGGAGGA
CTGATTCGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT218177 WP_000362050.1 NZ_CP084194:c4698107-4697817 [Salmonella sp. A39]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT218177 NZ_CP115669:784958-785299 [Pseudomonas sp. PSE14]
ATGAACAACCTGCTACAGCACCGAGGCTATTACGGGTCCATCGAGGCCAGCCCCGAGGACAACTGCCTGTTCGGCAAGCT
GCTGTTCATCCGGGCCCTGGTCAATTACGAGGGCGAGACGGTCGCCGAGCTGGCCGGCGCGTTCCGCGCTGCGGTCGATG
ATTACCTGGCCGACTGTGCTGCAACGGGCGTAGAGCCTGAGATTCCCTGCAAGGGATCTTTCAATGTTCGCGTAGGGCAT
GAACTGCATATGGCGGCCAGCATTGCGGCTATCCAGCAGAACATCACACTGAACGATCTGACCCGCCGGGCGCTGAGCGA
GTACATCGAGCAGCACGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64