Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1903891..1904537 Replicon chromosome
Accession NZ_CP084168
Organism Klebsiella pneumoniae strain B17602

Toxin (Protein)


Gene name higB Uniprot ID A0A483PC41
Locus tag LDH50_RS09320 Protein ID WP_004216295.1
Coordinates 1904190..1904537 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LDH50_RS09315 Protein ID WP_002920557.1
Coordinates 1903891..1904190 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH50_RS09295 (LDH50_09295) 1900097..1900855 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
LDH50_RS09300 (LDH50_09300) 1900905..1901735 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LDH50_RS09305 (LDH50_09305) 1901786..1902115 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LDH50_RS09310 (LDH50_09310) 1902320..1903828 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LDH50_RS09315 (LDH50_09315) 1903891..1904190 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LDH50_RS09320 (LDH50_09320) 1904190..1904537 - 348 WP_004216295.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDH50_RS09325 (LDH50_09325) 1904713..1907160 - 2448 WP_134919826.1 glycogen phosphorylase -
LDH50_RS09330 (LDH50_09330) 1907178..1908611 - 1434 WP_004889438.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13606.61 Da        Isoelectric Point: 5.6749

>T218144 WP_004216295.1 NZ_CP084168:c1904537-1904190 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCADNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T218144 NZ_CP115654:c1593011-1592829 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT218144 WP_002920557.1 NZ_CP084168:c1904190-1903891 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT218144 NZ_CP115654:c1592726-1592325 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483PC41

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References