Detailed information of TA system TA218128

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2461323..2461507
• Replicon: chromosome
• Accession: NZ_CP084107
• Organism: Staphylococcus aureus strain CC49/ST49-MSSA

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: LB316_RS12215
• Protein ID: WP_000482647.1
• Coordinates: 2461400..2461507 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2461323..2461383 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB316_RS12200	2456707..2458470	-	1764	WP_001064819.1	ABC transporter ATP-binding protein	-
LB316_RS12205	2459031..2459792	-	762	WP_001066123.1	IS21-like element helper ATPase IstB	-
LB316_RS12210	2459785..2461077	-	1293	WP_000777467.1	IS21 family transposase	-
-	2461323..2461383	+	61	-	-	Antitoxin
LB316_RS12215	2461400..2461507	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
LB316_RS12220	2461641..2462027	-	387	WP_000779352.1	flippase GtxA	-
LB316_RS12225	2462295..2463437	+	1143	WP_001176863.1	glycerate kinase	-
LB316_RS12230	2463497..2464156	+	660	WP_000831298.1	membrane protein	-
LB316_RS12235	2464339..2465550	+	1212	WP_001191923.1	multidrug effflux MFS transporter	-
LB316_RS12240	2465673..2466146	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2459031..2459795	764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T218128 WP_000482647.1 NZ_CP084107:c2461507-2461400 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T218128 NZ_CP115625:13469-13825 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT218128 NZ_CP084107:2461323-2461383 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin