Detailed information of TA system TA218127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2433860..2434377
• Replicon: chromosome
• Accession: NZ_CP084107
• Organism: Staphylococcus aureus strain CC49/ST49-MSSA

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: LB316_RS12070
• Protein ID: WP_000113263.1
• Coordinates: 2433860..2434126 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LB316_RS12075
• Protein ID: WP_000584498.1
• Coordinates: 2434126..2434377 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB316_RS12040 (2429066)	2429066..2429602	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
LB316_RS12045 (2430067)	2430067..2430891	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
LB316_RS12050 (2431094)	2431094..2431276	-	183	WP_000079140.1	hypothetical protein	-
LB316_RS12055 (2431363)	2431363..2431830	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
LB316_RS12060 (2432016)	2432016..2433566	-	1551	WP_029754332.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
LB316_RS12065 (2433754)	2433754..2433825	-	72	WP_223200558.1	hypothetical protein	-
LB316_RS12070 (2433860)	2433860..2434126	-	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
LB316_RS12075 (2434126)	2434126..2434377	-	252	WP_000584498.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LB316_RS12080 (2434548)	2434548..2434639	-	92	Protein_2336	hypothetical protein	-
LB316_RS12085 (2434646)	2434646..2435245	-	600	WP_000162810.1	DsbA family protein	-
LB316_RS12090 (2435264)	2435264..2435626	-	363	WP_000819844.1	DUF4467 domain-containing protein	-
LB316_RS12095 (2435881)	2435881..2437131	+	1251	WP_001012239.1	FemA/FemB family glycyltransferase FmhA	-
LB316_RS12100 (2437228)	2437228..2437959	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
LB316_RS12105 (2437956)	2437956..2438675	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T218127 WP_000113263.1 NZ_CP084107:c2434126-2433860 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T218127 NZ_CP115624:c27427-27068 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGTCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTATGGAGATAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9449.64 Da
• Isoelectric Point: 4.3407

>AT218127 WP_000584498.1 NZ_CP084107:c2434377-2434126 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNLNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT218127 NZ_CP115624:c27068-26769 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9