Detailed information of TA system TA218121

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1871213..1871393
• Replicon: chromosome
• Accession: NZ_CP084107
• Organism: Staphylococcus aureus strain CC49/ST49-MSSA

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LB316_RS09020
• Protein ID: WP_001801861.1
• Coordinates: 1871213..1871308 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1871336..1871393 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB316_RS08980	1866679..1867674	+	996	WP_020977362.1	DUF4352 domain-containing protein	-
LB316_RS08985	1867750..1868376	+	627	WP_000669045.1	hypothetical protein	-
LB316_RS08990	1868417..1868758	+	342	WP_000627534.1	DUF3969 family protein	-
LB316_RS08995	1868859..1869431	+	573	WP_000414218.1	hypothetical protein	-
LB316_RS09000	1869949..1870125	-	177	WP_000375478.1	hypothetical protein	-
LB316_RS09005	1870136..1870458	-	323	Protein_1773	hypothetical protein	-
LB316_RS09010	1870485..1870688	-	204	WP_225970890.1	IS3 family transposase	-
LB316_RS09015	1870832..1871068	-	237	WP_000251969.1	IS3 family transposase	-
LB316_RS09020	1871213..1871308	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1871336..1871393	-	58	-	-	Antitoxin
LB316_RS09025	1871431..1871495	+	65	Protein_1777	hypothetical protein	-
LB316_RS09030	1871524..1871679	+	156	WP_001215823.1	hypothetical protein	-
LB316_RS09035	1872249..1872692	-	444	WP_000728661.1	DUF1433 domain-containing protein	-
LB316_RS09040	1872692..1873135	-	444	WP_000731420.1	DUF1433 domain-containing protein	-
LB316_RS09045	1873135..1873578	-	444	WP_000747798.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / lukD / hlgA	1865190..1899975	34785
	-	flank	IS/Tn	-	-	1870832..1871068	236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T218121 WP_001801861.1 NZ_CP084107:1871213-1871308 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T218121 NZ_CP115604:477543-477893 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT218121 NZ_CP084107:c1871393-1871336 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin